April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Comparative Study of Upper Eyelid Position Interdependence in Involutional Ptosis Patients Submitted to 1, 2 or 4 Drops of 10% Phenylephrine
Author Affiliations & Notes
  • S. Matayoshi
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • E. M. S. Macedo
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • R. C. Carneiro
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • P. Lunardelli
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • I. M. Yamakami
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • F. M. Silva
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • T. N. Pereira
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • V. Meuleman
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • M. Lavezzo
    Ophthalmology, Faculdade de Medicina USP, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  S. Matayoshi, None; E.M.S. Macedo, None; R.C. Carneiro, None; P. Lunardelli, None; I.M. Yamakami, None; F.M. Silva, None; T.N. Pereira, None; V. Meuleman, None; M. Lavezzo, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1478. doi:https://doi.org/
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      S. Matayoshi, E. M. S. Macedo, R. C. Carneiro, P. Lunardelli, I. M. Yamakami, F. M. Silva, T. N. Pereira, V. Meuleman, M. Lavezzo; Comparative Study of Upper Eyelid Position Interdependence in Involutional Ptosis Patients Submitted to 1, 2 or 4 Drops of 10% Phenylephrine. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1478. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The primary aim of this study is quantify and compare upper eyelid position changes in tested and opposite eyes in ptosis patients submitted to 1, 2 or 4 drops of 10% phenylephrine in one eye.

Methods: : This is a prospective observational study conducted in involutional ptosis patients, submitted to the instillation of a single drop of 10% phenylephrine in one eye(Group 1=18 cases), 2 drops (G2=19 cases) or 4 drops ( G3= 17 cases).images of both eyes were video camera recorded before and after drug application at 3, 10, 15 and 30 minutes. The images were edited to analyze upper and lower lid height.

Results: : All cases presented upper lid elevation in tested eyes, G1 showed the least elevation (1.22±0.53mm) compared to the other two groups (G2=2.35±1.12mm and G3=3.01±1.13mm).The opposite eye showed upper lid drooping in all cases (between 1.08±0.62mm and 1.31 ±0.38mm), G2 and G3 presented higher changes than group 1.

Conclusions: : Upper eyelid elevation in tested eyes was significantly lower in single drop group. In the opposite eye, lid position interdependence could be noticed because upper eyelid dropping occurred in all cases but in a higher proportion in G2 and G3. Eyelid height changes were best demonstrated using 2 drops of 10% phenylephrine.

Clinical Trial: : www.clinicaltrials.gov 00864656

Keywords: eyelid • eye movements: recording techniques • drug toxicity/drug effects 
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