Comparative Study of Upper Eyelid Position Interdependence in Involutional Ptosis Patients Submitted to 1, 2 or 4 Drops of 10% Phenylephrine

Abstract

Purpose: : The primary aim of this study is quantify and compare upper eyelid position changes in tested and opposite eyes in ptosis patients submitted to 1, 2 or 4 drops of 10% phenylephrine in one eye.

Methods: : This is a prospective observational study conducted in involutional ptosis patients, submitted to the instillation of a single drop of 10% phenylephrine in one eye(Group 1=18 cases), 2 drops (G2=19 cases) or 4 drops ( G3= 17 cases).images of both eyes were video camera recorded before and after drug application at 3, 10, 15 and 30 minutes. The images were edited to analyze upper and lower lid height.

Results: : All cases presented upper lid elevation in tested eyes, G1 showed the least elevation (1.22±0.53mm) compared to the other two groups (G2=2.35±1.12mm and G3=3.01±1.13mm).The opposite eye showed upper lid drooping in all cases (between 1.08±0.62mm and 1.31 ±0.38mm), G2 and G3 presented higher changes than group 1.

Conclusions: : Upper eyelid elevation in tested eyes was significantly lower in single drop group. In the opposite eye, lid position interdependence could be noticed because upper eyelid dropping occurred in all cases but in a higher proportion in G2 and G3. Eyelid height changes were best demonstrated using 2 drops of 10% phenylephrine.

Clinical Trial: : www.clinicaltrials.gov 00864656

Keywords: eyelid • eye movements: recording techniques • drug toxicity/drug effects