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A. Viestenz, F. Spors, A. Langenbucher, S. Walter, W. Behrens-Baumann, J. Reupsch, M. B. Hoffmann; Minor Effect of Blue-Block Filtering on the Multifocal Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1483. doi: https://doi.org/.
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Blue-block filtering the visual input might reduce the risk of photic retinopathy. Potential side effects of this approach on visual perception have not been assessed at the neural level and an objective functional assessment of blue-block filtering on retinal processing is currently missing.
MfERGs were recorded monocularly after pupil dilation from 20 pseudophacic patients with a clear intraocular lens (IOL) for two conditions: (a) ‘Blue-block’ for stimulus perception through a yellow filter, which had the filter characteristics of the IOL HOYA AF1 YA60BB. (b) ‘Reference’ for stimulus perception through a neutral filter, which attenuates the effective stimulus intensity like the ‘blue-block’, but independent of the wavelength. 1st order kernel mfERGs were extracted for 61 visual field locations and averaged for five stimulus eccentricities. Amplitudes and implicit times were determined for the mfERG-components N1, P1, and N2.
Typical mfERGs were obtained for both conditions for all eccentricities. No significant differences for amplitudes and implicit times were obtained for the two conditions, apart from two exceptions: P1-amplitudes were slightly enhanced for ‘blue block’ (4.4 %; p=0.033) and N2-implicit were shorter for ‘blue block’ (0.42 ms; p=0.030).
The bipolar-cell dominated mfERG is largely unaffected by short-term effects of blue-block filtering. The induced change of the spectral composition of the stimulus does not greatly alter the activity at the input stage of the visual system, specifically the retinal network comprising photoreceptors, horizontal, and bipolar cells.
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Magdeburg ethics commission 14/08
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