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A. Muselier, Jr., M. Souchier, B. Mathieu, S. Grégoire, F. Nicot, F. Baudouin, L. Bretillon, A. M. Bron, C. Creuzot-Garcher; Ocular Surface Response in Contact Lens Wearers. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1542.
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To evaluate the ocular surface changes induced by contact lens wear.
Data of 7 tolerant contact lens wearers, 7 non-tolerant contact lens wearers and 7 healthy subjects were collected. Every patient underwent a thorough ophthalmic examination and tear osmolarity test, conjunctival impression cytology and meibomian lipid sampling. Symptoms, Break-Up Time (BUT), tear osmolarity, conjunctival expression of human leucocyte antigen (HLA) DR and meibomian fatty acid composition were evaluated.
Twenty one subjects (8 men and 13 women) were included (42 eyes). Symptoms reported by tolerant and non-tolerant contact lens wearers were as follows: superficial foreign body sensation (29% vs 21%), burning (14% vs 21%) and ocular dryness (28% vs 78%). No symptoms were reported by healthy subjects. There was no significant difference in tear osmolarity (p=0.63) and meibomian fatty acid composition (p=0.97) in both groups. Break-up time was significantly lower in tolerant (p<0.05) and non-tolerant (p<0.0001) contact lens wearers than in healthy subjects. The HLA-DR expression was significantly higher in non-tolerant (50%) contact lens wearers than in healthy subjects (16%) (p<0.01).
Contact lens wear is responsible for ocular surface alterations which lead to intolerance. These patterns are very similar to those reported in dry eye symptoms.
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