April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Experimental Observation of Bevacizumab for Depressing the Immune Rejection After High-Risk Penetrating Keratoplasty in Rabbits
Author Affiliations & Notes
  • E. Guo
    SHENZHEN EYE HOSPITAL, SHENZHEN, China
  • Lina Huang
    SHENZHEN EYE HOSPITAL, SHENZHEN, China
  • Footnotes
    Commercial Relationships  E. Guo, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1557. doi:
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    • Get Citation

      E. Guo, Lina Huang; Experimental Observation of Bevacizumab for Depressing the Immune Rejection After High-Risk Penetrating Keratoplasty in Rabbits. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1557.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To observe the effect of Avastin eyedrops on immune rejection after high-risk keratoplasty in rabbits.

Methods: : Alkali-burn was used to establish neovascularization animal model. Allograft corneal transplantation was performed. . Avastin group: 0.25% Avastin eyedrops were used once a day for four weeks; at the same time 0.3% ofloxcine eyedrops was applied on control group. The time and degree of rejection were observed, and CD 4+ ,CD8+ cells infiltration were also detected in the rejected grafts.

Results: : Corneal grafts of 5 eyes in control group were rejected within 24 days, the mean time of rejection is 20.6 days; 4 grafts were rejected in Avastin group more than one month after operation, the mean time is 33 day. the difference between two groups is statistical significance.

Conclusions: : Avastin local application can delay immune rejection after penetrating keratoplasty in rabbits.

Keywords: cornea: stroma and keratocytes • cornea: epithelium • cornea: surface mucins 
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