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E. Guo, Lina Huang; Experimental Observation of Bevacizumab for Depressing the Immune Rejection After High-Risk Penetrating Keratoplasty in Rabbits. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1557.
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© ARVO (1962-2015); The Authors (2016-present)
To observe the effect of Avastin eyedrops on immune rejection after high-risk keratoplasty in rabbits.
Alkali-burn was used to establish neovascularization animal model. Allograft corneal transplantation was performed. . Avastin group: 0.25% Avastin eyedrops were used once a day for four weeks; at the same time 0.3% ofloxcine eyedrops was applied on control group. The time and degree of rejection were observed, and CD 4+ ,CD8+ cells infiltration were also detected in the rejected grafts.
Corneal grafts of 5 eyes in control group were rejected within 24 days, the mean time of rejection is 20.6 days; 4 grafts were rejected in Avastin group more than one month after operation, the mean time is 33 day. the difference between two groups is statistical significance.
Avastin local application can delay immune rejection after penetrating keratoplasty in rabbits.
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