April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
High Risk Histology in Eyes of Patients With Unilateral Retinoblastoma
Author Affiliations & Notes
  • Y. Shildkrot
    Ophthalmology, Univ of Tennessee Health Sci Ctr, Hamilton Eye Institute, Memphis, Tennessee
  • C. Rodriguez-Galindo
    Solid Tumor Division,
    St Jude Children's Research Hospital, Memphis, Tennessee
  • I. Qaddoumi
    Solid Tumor Division,
    St Jude Children's Research Hospital, Memphis, Tennessee
  • B. G. Haik
    Ophthalmology, Univ of Tennessee Health Sci Ctr, Hamilton Eye Institute, Memphis, Tennessee
  • M. W. Wilson
    Ophthalmology, Univ of Tennessee Health Sci Ctr, Hamilton Eye Institute, Memphis, Tennessee
    Division of Surgery, Division of Pathology,
    St Jude Children's Research Hospital, Memphis, Tennessee
  • Footnotes
    Commercial Relationships  Y. Shildkrot, None; C. Rodriguez-Galindo, None; I. Qaddoumi, None; B.G. Haik, None; M.W. Wilson, None.
  • Footnotes
    Support  Research to Prevent Blindness, Inc, New York, New York; St Giles Foundation, New York, New York.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1578. doi:https://doi.org/
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      Y. Shildkrot, C. Rodriguez-Galindo, I. Qaddoumi, B. G. Haik, M. W. Wilson; High Risk Histology in Eyes of Patients With Unilateral Retinoblastoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1578. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the severity of clinically-based patient classification with the incidence of high risk histopathology in primarily enucleated eyes of patients with unilateral retinoblastoma. Classification systems of interest were International (ICRB), Reese-Ellsworth (RE), and American Joint Committee on Cancer clinical T(NM) classification (cT)..

Methods: : Retrospective chart review.

Results: : 205 eyes of 236 patients with unilateral disease were enucleated between 1958 and 2009. For 160 primarily enucleated eyes adequate histologic and clinical information was available. Severity of RE classification had poor correspondence (p > 0.09) with high risk histopathologic features, which were present in 55/146 (37.6%) group V eyes, 2/5 (40%) Group IV, 0/12 Group III, 1/1 (100%) Group II. Better correspondence (p < 0.02) was observed for the ICRB ,where 39/82 (47.5%) Group E eyes, 18/67(26.9%) Group D eyes, 1/7 (14.3%) Group C eyes and 0/4 Group B eyes harbored high risk features. The best correspondence with the high risk pathology (p<0.006) was observed for cT: 3/3 (100%) stage 4 eyes, 7/11 (64%) Stage 3, 47/135 (35%) Stage 2, 1/11 (9%) Stage 1 eyes had at least one of the high risk features.

Conclusions: : No single clinical classification system for retinoblastoma is absolutely accurate in predicting histologic features in primarily enucleated eyes. ICRB and AJCC clinical T systems had the best correspondence with the presence of high risk histopathologic features in the eyes of patients with unilateral retinoblastoma.

Keywords: retinoblastoma • oncology • pathology: human 
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