April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Evaluation of Ntf4 as a Candidate Gene for Primary Open Angle Glaucoma
M. Zhang; J. Wang; H. Chen; L.-J. Chen; P. Tam; C. Tham; C. Pang
Author Affiliations & Notes
  • M. Zhang
    Ophthalmology, Joint Shantou International eye center, Shantou, China
  • J. Wang
    Ophthalmology, Joint Shantou International eye center, Shantou, China
  • H. Chen
    Ophthalmology, Joint Shantou International eye center, Shantou, China
  • L.-J. Chen
    Ophthalmology, Joint Shantou International eye center, Shantou, China
  • P. Tam
    Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • C. Tham
    Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • C. Pang
    Ophthalmology, Joint Shantou International eye center, Shantou, China
    Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Footnotes
    Commercial Relationships  M. Zhang, None; J. Wang, None; H. Chen, None; L.-J. Chen, None; P. Tam, None; C. Tham, None; C. Pang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1641. doi:
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      M. Zhang, J. Wang, H. Chen, L.-J. Chen, P. Tam, C. Tham, C. Pang; Evaluation of Ntf4 as a Candidate Gene for Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1641.

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Abstract

Purpose: : The neutrophic factor 4 (NTF4) gene has recently been reported to be associated with primary open angle glaucoma (POAG). We investigate sequence alterations in NTF4 among two Chinese cohorts.

Methods: : The study cohorts included 100 POAG patients and controls recruited in Shantou, a city in southern China, and another 180 PAOG patients and 230 controls recruited in Hong Kong. The coding exons and splice regions of NTF4 were screened by direct DNA sequencing after PCR.

Results: : Among all the study subjects, only one novel synonymous variant, c.453G>A (p.Pro151Pro), was identified in a patient with high-tension glaucoma in the Hong Kong. No sequence change was detected in the 230 Hong Kong controls from or the 200 Shantou subjects.

Conclusions: : The NTF4 gene seems unlikely to be a disease-causing gene of POAG in Chinese populations. Otherwise, its contribution is much lower than that in the Caucasian population (1.7%).

Keywords: gene screening 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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