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M. Zhang, J. Wang, H. Chen, L.-J. Chen, P. Tam, C. Tham, C. Pang; Evaluation of Ntf4 as a Candidate Gene for Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1641.
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The neutrophic factor 4 (NTF4) gene has recently been reported to be associated with primary open angle glaucoma (POAG). We investigate sequence alterations in NTF4 among two Chinese cohorts.
The study cohorts included 100 POAG patients and controls recruited in Shantou, a city in southern China, and another 180 PAOG patients and 230 controls recruited in Hong Kong. The coding exons and splice regions of NTF4 were screened by direct DNA sequencing after PCR.
Among all the study subjects, only one novel synonymous variant, c.453G>A (p.Pro151Pro), was identified in a patient with high-tension glaucoma in the Hong Kong. No sequence change was detected in the 230 Hong Kong controls from or the 200 Shantou subjects.
The NTF4 gene seems unlikely to be a disease-causing gene of POAG in Chinese populations. Otherwise, its contribution is much lower than that in the Caucasian population (1.7%).
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