April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Lens Opacity and Refractive Influences on Retinal Vascular Fractal Dimension Measurement
Author Affiliations & Notes
  • H. Li
    Center for Vision Research, The University of Sydney, Sydney, Australia
  • P. Mitchell
    Center for Vision Research, The University of Sydney, Sydney, Australia
  • G. Liew
    Center for Vision Research, The University of Sydney, Sydney, Australia
  • E. Rochtchina
    Center for Vision Research, The University of Sydney, Sydney, Australia
  • T. Y. Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Singapore Eye Research Institute,
    National University of Singapore, Singapore, Singapore
  • W. Hsu
    School of Computing,
    National University of Singapore, Singapore, Singapore
  • M. L. Lee
    School of Computing,
    National University of Singapore, Singapore, Singapore
  • Y. P. Zhang
    School of Electronic and Information Engineering, Ningbo University of Technology, Ning Bo, China
  • J. Wang
    Center for Vision Research, The University of Sydney, Sydney, Australia
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • Footnotes
    Commercial Relationships  H. Li, None; P. Mitchell, None; G. Liew, None; E. Rochtchina, None; T.Y. Wong, None; W. Hsu, None; M.L. Lee, None; Y.P. Zhang, None; J. Wang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1701. doi:
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      H. Li, P. Mitchell, G. Liew, E. Rochtchina, T. Y. Wong, W. Hsu, M. L. Lee, Y. P. Zhang, J. Wang; Lens Opacity and Refractive Influences on Retinal Vascular Fractal Dimension Measurement. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1701.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the influence of lens opacity and refraction on retinal vascular fractal dimension (Df) measurement.

Methods: : Right eye optic disc photographs of 3654 participants (aged 49-97 years) of the Blue Mountains Eye Study (1992-94) were digitized. Df of retinal vasculature was quantified using a computer-based program. Lens opacity scores were the sum of severity scores of nuclear, cortical and posterior subcapsular cataract, assessed from lens photographs. Refractive errors were measured using an autorefractor followed by subjective refraction. Spherical equivalent refraction (SER) was calculated as the sum of spherical plus 0.5 cylinder power. Axial length was measured at the 10-year follow-up examination using an IOL master.

Results: : Complete data were available in 2859 subjects. Mean Df of retinal vasculature was 1.444±0.023. Increasing lens opacity scores were associated with significant decrease in Df (β =-0.0030, p<0.0001). Cortical and posterior subcapsular cataract involving lens central area was associated with reduced Df, after controlling for age, gender, refraction and other confounding factors (p≤0.0105). Increasing myopic severity and axial length were associated with decreasing Df after adjusting for age, gender, height, body mass index, blood pressure and lens opacity scores (both ptrend <0.0001). The slope of Df decreasing per SER reduction was -0.0040 in eyes with SER≤-4D and -0.0016 in eyes with SER>-4D. SER remained significant after simultaneously adjusting for axial length.

Conclusions: : Ocular media opacity and refraction influence retinal vascular Df measurements. A myopic refraction of ≤-4D was associated with an additional reduction in Df, suggesting rarefaction of retinal vasculature associated with high myopia.

Keywords: clinical (human) or epidemiologic studies: outcomes/complications • imaging/image analysis: clinical • refraction 
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