April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Early Eye Development in Rhesus Monkeys Reared Under Different Monochromatic Illumination
Author Affiliations & Notes
  • R. Liu
    Eye & ENT Hospital, Fudan University, Shanghai, China
  • R.-Y. Chu
    Eye & ENT Hospital, Fudan University, Shanghai, China
  • J. He
    New England College of Optometry, Boston, Massachusetts
  • X.-T. Zhou
    Eye & ENT Hospital, Fudan University, Shanghai, China
  • J.-H. Dai
    Eye & ENT Hospital, Fudan University, Shanghai, China
  • X.-M. Qu
    Eye & ENT Hospital, Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships  R. Liu, None; R.-Y. Chu, None; J. He, None; X.-T. Zhou, None; J.-H. Dai, None; X.-M. Qu, None.
  • Footnotes
    Support  National Nature Science Foundation of China (30530770)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1735. doi:
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      R. Liu, R.-Y. Chu, J. He, X.-T. Zhou, J.-H. Dai, X.-M. Qu; Early Eye Development in Rhesus Monkeys Reared Under Different Monochromatic Illumination. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1735.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Influence of longitudinal chromatic aberration (LCA) on emmetropization during early eye development has been studied for the chicken and fish, but not for the primates. Purpose of this study is to investigate the effects of quasi-monochromatic lighting on refractive development and eye growth in rhesus monkeys.

Methods: : Infant rhesus monkeys were raised under three different illumination conditions: quasi-monochromatic blue light (peaked at 455nm), red light (peaked at 610nm) and white light (color temperature 5000K) respectively. All subjects underwent biometric measurements including refraction, corneal power and axial components before the treatment and during 51 weeks of treatment period.

Results: : Two out of the five monkeys reared under red lighting condition developed myopia with a mean myopic refractive error of -2.75±0.46D, that was significantly lower than the mean hyperopic error of 1.29±0.64D from the three other monkeys from the same red lighting condition (t=7.85, P<0.0001). Mean change in vitreous chamber depth of the two myopic monkeys was significantly greater than that of the other three red lighting monkeys (t=-5.16, P<0.0001). Significant difference in mean refractive error was first observed at the 38th week from the treatment and maintained until the end of observation, with a more hyperopic refractive error in the blue lighting group than those from the red and white lighting groups.

Conclusions: : Illumination of long-wavelength light during early life seems to be a risk factor for rhesus monkey to develop myopia and chromatic system in primates might play a role in the process of early eye development.

Keywords: refractive error development • chromatic mechanisms • myopia 
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