April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Safety of Intraocular Linezolid in Rabbits
Author Affiliations & Notes
  • S. L. Duke
    Ophthalmology and Visual Sciences,
    University of Nebraska Medical Center, Omaha, Nebraska
  • L. Kump
    Ophthalmology and Visual Sciences,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Y. Yuan
    Genetics, Cell Biology and Anatomy,
    University of Nebraska Medical Center, Omaha, Nebraska
  • W. West
    Pathology and Microbiology,
    University of Nebraska Medical Center, Omaha, Nebraska
  • A. Sachs
    Genetics, Cell Biology and Anatomy,
    University of Nebraska Medical Center, Omaha, Nebraska
  • N. Haider
    Genetics, Cell Biology and Anatomy,
    University of Nebraska Medical Center, Omaha, Nebraska
  • E. Margalit
    Ophthalmology and Visual Sciences,
    University of Nebraska Medical Center, Omaha, Nebraska
  • Footnotes
    Commercial Relationships  S.L. Duke, None; L. Kump, None; Y. Yuan, None; W. West, None; A. Sachs, None; N. Haider, None; E. Margalit, None.
  • Footnotes
    Support  This study was supported in part by an unrestricted grant from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 1993. doi:
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    • Get Citation

      S. L. Duke, L. Kump, Y. Yuan, W. West, A. Sachs, N. Haider, E. Margalit; The Safety of Intraocular Linezolid in Rabbits. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1993.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Intraocular injections of linezolid, a synthetic oxazolidinone antibiotic, were performed in rabbits to assess its safety as a possible treatment for endophthalmitis.

Methods: : 300 µg/0.1 cc, 200 µg/0.1 cc or 100 µg/0.1 cc of linezolid was injected into the vitreous of the right eye of 12 rabbits. Balanced saline solution (BSS) was injection into the left eye of each rabbit as a control. A standard electroretinogram (ERG) was obtained before injection and repeated 2 days and 1 and 4 weeks after injection. Intraocular pressure (IOP) was also measured post-injection. After the experiment, the rabbits were euthanized and the retinas were examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure and histopathology between the two eyes were recorded.

Results: : There were no statistically significant differences in the electroretinograms obtained between the linezolid-injected eyes and the control eyes. No histopathologic changes were observed in study eyes compared with control eyes.

Conclusions: : Preservative-free linezolid is nontoxic to the retinas of rabbits when injected intravitreally and thus can be considered as a method of administration for linezolid in the treatment of endophthalmitis.

Keywords: antibiotics/antifungals/antiparasitics • endophthalmitis • electroretinography: non-clinical 
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