Purchase this article with an account.
S. L. Duke, L. Kump, Y. Yuan, W. West, A. Sachs, N. Haider, E. Margalit; The Safety of Intraocular Linezolid in Rabbits. Invest. Ophthalmol. Vis. Sci. 2010;51(13):1993.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Intraocular injections of linezolid, a synthetic oxazolidinone antibiotic, were performed in rabbits to assess its safety as a possible treatment for endophthalmitis.
300 µg/0.1 cc, 200 µg/0.1 cc or 100 µg/0.1 cc of linezolid was injected into the vitreous of the right eye of 12 rabbits. Balanced saline solution (BSS) was injection into the left eye of each rabbit as a control. A standard electroretinogram (ERG) was obtained before injection and repeated 2 days and 1 and 4 weeks after injection. Intraocular pressure (IOP) was also measured post-injection. After the experiment, the rabbits were euthanized and the retinas were examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure and histopathology between the two eyes were recorded.
There were no statistically significant differences in the electroretinograms obtained between the linezolid-injected eyes and the control eyes. No histopathologic changes were observed in study eyes compared with control eyes.
Preservative-free linezolid is nontoxic to the retinas of rabbits when injected intravitreally and thus can be considered as a method of administration for linezolid in the treatment of endophthalmitis.
This PDF is available to Subscribers Only