Purchase this article with an account.
M. D. Bailey, L. T. Sinnott; The Relationship Between Refractive Error and Globe Dimensions. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2008.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relationship between refractive error, axial length, the anterior scleral chord, and the globe asymmetry ratio.
Subjects were 83 children with a mean ± SD age of 9.6 ± 2.7 years, and 53% of the subjects were female. Cycloplegic, spherical equivalent refractive error was measured with the Grand Seiko autorefractor, and axial length (AL) was measured with the IOLMaster. The anterior scleral chord (ASC), the width of the globe at the anterior-posterior midpoint of the crystalline lens, was measured from VisanteTM images of the anterior segment in the horizontal dimension. The globe asymmetry ratio was defined as AL/ASC. Correlation coefficients among the refractive error and globe shape variables were calculated, and multiple regressions of refractive error with AL only, AL and ASC, and AL, ASC, age, and gender were fitted.
The mean ± SD refractive error was –0.50 ± 2.04 D (range: –6.00 to +6.42). Significant correlations were found between refractive error and axial length (r = –0.78, p < 0.001) and the globe asymmetry ratio (r = –0.79, p < 0.001), but not for ASC (r = 0.02, p > 0.05). In a multiple regression, however, axial length and ASC were both statistically significant predictors of refractive error (R2 = 0.80, both p ≤ 0.0001), even after controlling for age (p = 0.06) and gender (p = 0.0001). A regression of refractive error and axial length only had an R2 = 0.61, p < 0.0001.
The width of the globe, as measured by ASC, is a non-optical, ocular component measurement that appears to provide information about refractive error in addition to what is explained by the axial length of the eye. These data suggest that the ASC variable should be considered in conjunction with axial length measurements in future longitudinal studies, as it may be valuable in models for predicting myopia development.
This PDF is available to Subscribers Only