April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Patients Blinded by Outer Retinal Dystrophies Are Able to Identify Letters Using the Argus TM II Retinal Prosthesis System
Author Affiliations & Notes
  • L. daCruz
    Moorfields Eye Hospital, London, United Kingdom
  • B. Coley
    Second Sight, Geneva, Switzerland
  • P. Christopher
    Second Sight, LA, California
  • F. Merlini
    Second Sight, Geneva, Switzerland
  • V. Wuyyuru
    Second Sight, LA, California
  • J. A. Sahel
    Quinze-Vingts, Paris, France
  • P. Stanga
    Manchester Royal Eye Hospital, Manchester, United Kingdom
  • E. Filley
    Retina Foundation Southwest, Dallas, Texas
  • G. Dagnelie
    Johns Hopkins Univ, Baltimore, Maryland
  • Argus II Study Group
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  L. daCruz, Second Sight Medical products Inc., F; B. Coley, Second Sight Medical Products Inc., E; P. Christopher, Second Sight Medical Products Inc., E; F. Merlini, Second Sight Medical Products Inc., E; V. Wuyyuru, Second Sight Medical Products Inc., E; J.A. Sahel, Second Sight Medical products Inc., F; P. Stanga, Second Sight Medical products Inc., F; E. Filley, Second Sight Medical products Inc., F; G. Dagnelie, Second Sight Medical products Inc., F.
  • Footnotes
    Support  NIH Grant 5R01EY12893
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2023. doi:https://doi.org/
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      L. daCruz, B. Coley, P. Christopher, F. Merlini, V. Wuyyuru, J. A. Sahel, P. Stanga, E. Filley, G. Dagnelie, Argus II Study Group; Patients Blinded by Outer Retinal Dystrophies Are Able to Identify Letters Using the Argus TM II Retinal Prosthesis System. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2023. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To test if patients blinded by outer retinal dystrophies and fitted with the Argus II Retinal Prosthesis System, can identify letters on a computer monitor.

Methods: : Blind subjects (vision reduced to bare light perception or worse) fitted with the Argus II Retinal Prosthesis were asked to identify white letters on a black background, on an LCD computer monitor in a forced-choice closed-set test. For the test, 22 subjects were presented the letters L,T,E,J,F,H,I,U (group A); 11 subjects the letters A,Z,Q,V,N,W,O,C,D,M (group B) and 6 subjects the letters K,R,G,X,B,Y,S,P (group C). Letters were Power Point, Century Gothic, 600 point viewed at 12 inches. The letters were presented in random order, 4 times with the System on and 4 times with the System off. The time taken to identify the letter correctly was recorded.

Results: : The mean percent correct and standard deviations for all subjects tested were as follows. Group A 72.6 ± 24.2 % system on and 16.8 ± 10.0% system off, Group B 61.4 ± 30.0% system on and 9.5% ± 5.9% system off, and group C 63.5% ± 28.3% system on and 17.2% ± 1.7% system off. Using a Chi squared test there was a significant difference between systems on and off for each group (p < 0.001). The average time for the letters to be correctly identified was 44.8s group A, 62.3s Group B and 100.3s Group C with System on.

Conclusions: : Blind patients fitted with the Argus II Retinal Prosthesis System were able to perform significantly better with the system on compared with off in a forced-choice, closed-set, letter identification task. This is the first time that a retinal prosthetic device has been shown to allow a large group of blind patients to successfully identify letters.

Clinical Trial: : www.clinicaltrials.gov NCT00407602

Keywords: retina • shape, form, contour, object perception • degenerations/dystrophies 
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