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S. Frenkel, J. Levy, M. Neufeld, J. Pe'er; Calcifications in Retinoblastoma: Histologic Findings and Statistical Analysis of 302 Cases. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2074.
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Dystrophic calcification is encountered mostly in areas of necrosis. Calcification in retinoblastoma is a frequent histologic finding with a reported frequency between 50% and 95%, although the subject has not been studied in depth. To the best of our knowledge, no previous studies have addressed the relationship between calcifications and other histologic features in retinoblastoma. The purpose of this study is to evaluate the histological factors that may affect the development of calcifications in eyes with retinoblastoma.
Three hundred and two enucleated eyes examined at the Ophthalmic Pathology Laboratory at the Hadassah-Hebrew University Medical Center, Jerusalem, Israel, between the years 1960 and 2008, were retrospectively reviewed. Histologic slides were evaluated for the presence and degree of calcifications as well for other histologic features. Univariate and multivariate statistical analyses were performed to search for a possible correlation between calcifications and the other histologic factors.
Calcification was present in 84.9% of cases. Age, tumor size, necrosis, basophilic staining, iris neovascularization, choroidal, scleral and/or optic nerve invasion were correlated significantly with calcifications. Multivariate analysis showed a significant correlation only between the presence of calcifications and the amount of necrosis and choroidal invasion.
In our series calcifications were more frequent in cases with more necrosis and cases with choroidal invasion. The possible clinical implication of our findings deserves additional studies.
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