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B. Gupta, I. MacDougall, C. Sharpe, S. Jayawardene, T. A. Bailey, S. Sivaprasad; Ocular Manifestations in Patients With Diabetes-Related End Stage Renal Disease in Various Ethnic Groups (DRIVE UK Study). Invest. Ophthalmol. Vis. Sci. 2010;51(13):2079.
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Diabetic Retinopathy in various ethnic groups in UK (DRIVE UK) is an epidemiological study looking at prevalence of diabetic retinopathy in different ethnic groups (mainly Caucasians, Afro-Caribbeans, and South Asians) in UK. This data was collected as part of this study.Aim of the study: To study the differences in severity of diabetic retinopathy and other ocular co-morbidities in patients with diabetic end stage renal disease (ESRD) in various ethnic groups.
Materials and Methods: :
This cross-sectional population-based study identified the patients with diabetes from the diabetic eye complication screening services (DECS) and hospital renal services in South East London. Data collected included baseline demographics, date of diagnosis of diabetes and ESRD, type of diabetes and associated systemic risk factors. Longitudinal regression analysis was done to adjust for age, gender, HbA1c at the time of diagnosis of ESRD, lipid profile, hypertension, smoking, peripheral vascular disease, neuropathy, macrovascular complications and renal function tests. Comparison of disease severity between ethnic groups was done using ANOVA analysis.
Out of the total of 167 patients with ESRD, there were Afro Caribbean (n=59), Caucasian (N=76), South Asians (n= 19), and others (n=13). The mean duration of diabetes to onset of ESRD was longer in Caucasian (26.19 years) followed by Afro Caribbean (20.81 years and Asians (19.21 years) respectively. The rate of PDR was maximum in Caucasian in 58.97% and least in Asian (36.24%). This was statistically significant. (p< 0.05). However, the highest rates of maculopathy (52.54%) were in Afro Caribbean’s with least in Asians (36.84%). This was statistically significant. (p< 0.05). Cataract rate was highest in Afro Caribbean (22.84%) with least in Caucasian ( 12.84%).
Ocular manifestations in patients with diabetes related ESRD vary significantly between ethnic groups. It is important to consider ethnicity of an individual in the management of eye diseases in diabetes.Acknowledgement: Funded by Guide Dogs for the Blind.
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