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Y. Ikeda, K. Mori, M. Ueno, K. Imai, T. Yagi, N. Omi, Y. Tokuda, M. Fuwa, K. Tashiro, S. Kinoshita; Association Between General Systematic Disease and the Marker Snps for Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2164.
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We reported the 6 significant single nucleotide polymorphisms (SNPs) for primary open-angle glaucoma (POAG) by the whole genome and custom gene chip analysis in the journal of Proceedings of the National Academy of Sciences in July 2009. In this study, we analyze the association between those 6 SNPs and general systematic disease.
From 826 POAG patients and 748 normal subjects with no glaucoma or family history of glaucoma, we enrolled 745POAG patients (366 males and 379 females; mean age: 64.4±13.5 years) and 682 normal subjects (270 males and 412 females; mean age: 55.3±14.3 years) who answered an interview about their general diseases. Based on their answers, chi square tests were used to analyze the association between the high rate of 6 diseases/disorders (neurovascular disorder, cardiovascular disorder, diabetes mellitus, hyperlipidemia, hypertension, and peripheral circulatory disorder) and 6 SNPs ((1)rs547984, (2)rs540782, (3)rs693421, (4)rs2499601, (5)rs7081455, and (6)rs7961953).
The prevalence of neurovascular disorder, cardiovascular disorder, diabetes mellitus, hyperlipidemia, hypertension, and peripheral circulatory disorder for the POAG patients/normal subjects were 2.6/0.4%, 12.1/6.5%, 9.3/3.8%, 10.3/11.0%, 22.1/15.5%, and 56.5/64.1%, respectively. Except for hyperlipidemia and peripheral circulatory disorder, the prevalence rate was significantly higher in the POAG patients than in the normal subjects (p<0.05). Only for diabetes mellitus was the prevalence rate significantly higher in POAG patients having SNPs 1 through 4 than that in normal subjects (p<0.05). However, there was no significant prevalence rate of the 6 disease/disorders between POAG and normal subjects in which the 6 SNPs were analyzed. It should be noted that SNPs 1 through 4 were in the same chromosome: chromosome 1.
The results of this study show that careful consideration should be given toward the possibility of the influences of diabetes mellitus on POAG SNPs analysis.
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