April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Interaction Between Endothelial Nitric Oxide Synthase Gene Variants and Hypertension in Relation to Primary Open-Angle Glaucoma
Author Affiliations & Notes
  • W. S. Abdrabou
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • J. Kang
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts
  • J. Wiggs
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • B. A. Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts
  • S. E. Hankinson
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts
  • J. Haines
    Center for Human Genetic Research, Vanderbilt University School of Medicine, Nashville, Tennessee
  • L. R. Pasquale
    Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  W.S. Abdrabou, None; J. Kang, None; J. Wiggs, None; B.A. Rosner, None; S.E. Hankinson, None; J. Haines, None; L.R. Pasquale, None.
  • Footnotes
    Support  NIH grants CA87969; CA55075; EY09611; R01EY015473; HL35464; P30EY014104-06; the Massachusetts Lions Eye Research Fund and Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2173. doi:
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      W. S. Abdrabou, J. Kang, J. Wiggs, B. A. Rosner, S. E. Hankinson, J. Haines, L. R. Pasquale; The Interaction Between Endothelial Nitric Oxide Synthase Gene Variants and Hypertension in Relation to Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2173.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the interaction between nitric oxide synthase gene (NOS3) variants and hypertension in relation to primary open-angle glaucoma (POAG).

Methods: : Two functional single nucleotide polymorphisms (SNPs)( T-786C: rs2070744, Glu298Asp: rs1799983) and three tagging SNPs (rs7830; rs3918188; rs1800779) were evaluated in nested case-control studies from the Nurses’ Health Study (followed 1980 - 2002) and the Health Professionals’ Follow-up Study (followed 1986 - 2002). Participants were aged ≥ 40 years and Caucasian. Hypertension was defined as ever having had a diagnosis of hypertension; this information has been updated from baseline to 2002 in both cohorts. We included 527 incident cases and 1543 controls, matched on cohort, age and eye exam at the matched cases’ diagnosis dates. Cohort-specific relative risks (RR) were estimated using multivariable conditional logistic regression and pooled with meta-analysis.

Results: : Hypertension was not associated with POAG. We observed significant interactions between the promoter T-786C SNP and hypertension in relation to overall POAG (p for interaction = 0.02): among those with the genotype TT, hypertension was significantly adversely associated with risk of POAG (RR=1.45, 95% CI = 1.01, 2.08). However, among those carrying the variant allele (C), hypertension was not associated with POAG risk (RR=1.23, [95% CI 0.82, 1.86] for those without hypertension, RR=1.12, [95% 0.80, 1.57] for those with hypertension). Similar interactions were observed with the SNP rs1800779.

Conclusions: : Interactions were observed between hypertension and NOS3 SNPs in relation to risk of POAG.

Keywords: clinical (human) or epidemiologic studies: natural history • genetics • nitric oxide 
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