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P. Lazon De La Jara, P. Sankaridurg, A. Ho, A. Martinez, L. Donovan, E. L. Smith, III, X. Chen, J. Ge, B. Holden, The Vision CRC Myopia Control Study Group; A Silicone Hydrogel Contact Lens Produced Less Myopia Progression Than Single Vision Spectacles in Chinese Children Over a 6 Month Period. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2198.
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To compare myopia progression in Chinese children after 6 months wear of single vision spectacles (SPL) and single-vision silicone hydrogel contact lens (SHCL).
The myopia progression of 33 children wearing SPL and 43 children wearing SHCL (Lotrafilcon B, CIBA Vision) on a daily-wear basis, was compared at 6 months. Cycloplegic central autorefraction, peripheral refraction (Shin Nippon NVision K-5001) along the horizontal meridian (20°, 30° and 40° nasal and temporal fields) and axial length (AL) with IOLMaster were measured at the same institution by the same investigators. Inclusion criteria included age from 7 to 14 y/o; baseline refraction (Rx) from -0.75D to -3.50D sphere; and cylinder ≤ 0.50D. Multivariate analysis was performed to test for effect of lens type, after adjusting for parental myopia, gender, age and Rx on myopia progression. The combined data from the two groups were used to analyse the relationship between myopia progression and peripheral refraction at each field angle.
After adjusting for parental myopia, gender, age and Rx, myopia progression was 38% less (p<0.001) for SHCL (-0.37±0.29D) than SPL (-0.60±0.29D). Similarly, AL increase was 44% less (p<0.001) for SHCL (0.14±0.12 mm) than SPL (0.25±0.12 mm). Myopia progression was significantly affected by baseline age (p=0.031) but not by Rx or gender (p>0.05). Analysis of refraction results showed that SPL produced greater peripheral hyperopic defocus than SHCL for all field angles except for 40° nasal field (temporal retina).
The faster myopia progression observed for SPL may have been due to higher amounts of relative peripheral hyperopia with SPL than SHCL. Longer term follow-up is in progress.
Clinical Trial: :
www.chictr.org 00000029 & 00000232
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