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P. R. Sankaridurg, L. Donovan, S. Varnas, X. Chen, Z. Lin, S. Fisher, A. Ho, J. Ge, E. Smith, III, B. A. Holden; Progression of Myopia With Spectacle Lenses Designed to Reduce Relative Peripheral Hyperopia: 12 Months Results. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2206. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare rates of progression of myopia with normal sphero-cylindrical spectacle lenses (SPL) and spectacle lenses designed to slow the progress of myopia by reducing relative peripheral hyperopia (AMSPL).
As part of the Vision CRC Myopia Control Studies, 210 Chinese children aged 6 to 16 yrs and with myopia (sphere -0.75 to -3.50D with cylinder < -1.50D) were randomised to wear either one of three AMSPL or a SPL in a study conducted at Zhongshan Ophthalmic Centre from 2007 to 2008. Two of the AMSPL were rotationally symmetric with clear central zones surrounded by a progressively ramp of increasing positive power (up to +2.00D 25mm from centre). The third AMSPL was rotationally asymmetric, had clear centre and positive power in periphery (+1.90D, 25mm from centre) and was optimised to reduce astigmatism in the horizontal meridian. Cycloplegic autorefraction and axial length were recorded at 6 and 12 months and change from baseline averaged between right and left eyes. Myopia progression was compared between groups using linear mixed models and if significant, post-hoc multiple comparisons with Bonferroni correction performed.
Progression of myopia in the SPL group was -0.55±0.35D at 6 months and -0.78±0.50D at 12 months. Eyes wearing rotationally asymmetric AMSPL showed less progression (-0.47D±0.30D and -0.66D±0.41D at 6 and 12 months) but the differences were not statistically significant overall. In younger children (6 to 12 yrs) with at least one myopic parent, there was significantly less progression with rotationally asymmetric AMSPL compared to the SPL (-0.68±0.47D versus -0.97±0.48D, p=0.038).
One spectacle lens designed to reduce relative peripheral hyperopia slowed the progression of myopia in younger children with a parental history of myopia.
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