April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Progression of Myopia With Spectacle Lenses Designed to Reduce Relative Peripheral Hyperopia: 12 Months Results
P. R. Sankaridurg; L. Donovan; S. Varnas; X. Chen; Z. Lin; S. Fisher; A. Ho; J. Ge; E. Smith, III; B. A. Holden
Author Affiliations & Notes
  • P. R. Sankaridurg
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • L. Donovan
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • S. Varnas
    Carl Zeiss Vision, Adelaide, Australia
  • X. Chen
    Zhongshan Ophthalmic Centre, Guangzhou, China
  • Z. Lin
    Zhongshan Ophthalmic Centre, Guangzhou, China
  • S. Fisher
    Carl Zeiss Vision, Adelaide, Australia
  • A. Ho
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • J. Ge
    Zhongshan Ophthalmic Centre, Guangzhou, China
  • E. Smith, III
    Vision Cooperative Research Centre, Sydney, Australia
    College of Optometry, University of Houston, Houston, Texas
  • B. A. Holden
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • Footnotes
    Commercial Relationships  P.R. Sankaridurg, Institute for Eye Research, E; US20070159601, P; L. Donovan, Institute for Eye Research, E; S. Varnas, Carl Zeiss Vision, E; Inventor on patent application, P; X. Chen, None; Z. Lin, None; S. Fisher, Carl Zeiss Vision, E; A. Ho, Vision CRC, E; US7025460;US200701559601, P; J. Ge, None; E. Smith, III, US7025460;US20070159601, P; B.A. Holden, Institute for Eye Research, E; US7025460;US20070159601, P.
  • Footnotes
    Support  Funded by CRC and IER Research Grants with spectacles supplied by Carl Zeiss Vision.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2206. doi:
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      P. R. Sankaridurg, L. Donovan, S. Varnas, X. Chen, Z. Lin, S. Fisher, A. Ho, J. Ge, E. Smith, III, B. A. Holden; Progression of Myopia With Spectacle Lenses Designed to Reduce Relative Peripheral Hyperopia: 12 Months Results. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2206.

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Abstract

Purpose: : To compare rates of progression of myopia with normal sphero-cylindrical spectacle lenses (SPL) and spectacle lenses designed to slow the progress of myopia by reducing relative peripheral hyperopia (AMSPL).

Methods: : As part of the Vision CRC Myopia Control Studies, 210 Chinese children aged 6 to 16 yrs and with myopia (sphere -0.75 to -3.50D with cylinder < -1.50D) were randomised to wear either one of three AMSPL or a SPL in a study conducted at Zhongshan Ophthalmic Centre from 2007 to 2008. Two of the AMSPL were rotationally symmetric with clear central zones surrounded by a progressively ramp of increasing positive power (up to +2.00D 25mm from centre). The third AMSPL was rotationally asymmetric, had clear centre and positive power in periphery (+1.90D, 25mm from centre) and was optimised to reduce astigmatism in the horizontal meridian. Cycloplegic autorefraction and axial length were recorded at 6 and 12 months and change from baseline averaged between right and left eyes. Myopia progression was compared between groups using linear mixed models and if significant, post-hoc multiple comparisons with Bonferroni correction performed.

Results: : Progression of myopia in the SPL group was -0.55±0.35D at 6 months and -0.78±0.50D at 12 months. Eyes wearing rotationally asymmetric AMSPL showed less progression (-0.47D±0.30D and -0.66D±0.41D at 6 and 12 months) but the differences were not statistically significant overall. In younger children (6 to 12 yrs) with at least one myopic parent, there was significantly less progression with rotationally asymmetric AMSPL compared to the SPL (-0.68±0.47D versus -0.97±0.48D, p=0.038).

Conclusions: : One spectacle lens designed to reduce relative peripheral hyperopia slowed the progression of myopia in younger children with a parental history of myopia.

Clinical Trial: : www.chictr.org ChiCTR-TRC-00000029

Keywords: myopia • spectacle lens • refractive error development 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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