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B. A. Holden, P. Sankaridurg, P. Lazon de la Jara, E. L. Smith, III, X. Chen, J. Kwan, A. Martinez, A. Ho, J. Ge, The Vision CRC Myopia Control Study Group; Reduction in the Rate of Progress of Myopia With a Contact Lens Designed to Reduce Relative Peripheral Hyperopia. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2220.
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To determine if a silicone hydrogel contact lens designed to fully correct central vision but reduce relative peripheral hyperopia (AMCL) would reduce the rate of progress of myopia.
Rates of progress of myopia over 6 months of Chinese children with baseline myopia between sphere -0.75 to -3.50D and cylinder ≤0.50D, and aged 7 to 14 yrs, wearing AMCL (n=65) were compared to children (n=50) wearing normal sphero-cylindrical spectacles (SPL). Change in spherical equivalent refractive error (SphE) measured with cycloplegic auto-refraction and axial length (AL) at 6 months were the outcome measures. Myopia progression between groups was compared using linear mixed models and if significant, post-hoc multiple comparisons with Bonferroni corrections were performed.
Progression of myopia with AMCL was significantly less, -0.26±0.25D, than with SPL,-0.60±0.29D (p<0.01). Similarly, AL increase was less with AMCL, 0.08±0.11mm, compared to SPL, 0.25±0.12mm (p<0.01). Upon adjusting for type of lens, parental myopia, gender, age and baseline SphE values, estimated progression in SphE was -0.29D with AMCL (standard error (SE) 0.04, confidence interval (CI) -0.36 to -0.21D) compared with -0.63D ( SE 0.04, CI -0.72 to -0.55D) for SPL and for AL, 0.10mm, (SE 0.02mm, CI 0.07 to 0.14mm) with AMCL compared with 0.25mm (SE 0.02, CI 0.22 to 0.29mm) with SPL.
After 6 months of wear, progression of myopia with a contact lens designed to maintain clear central vision but reduce relative peripheral hyperopia was 54% less than that with standard sphero-cylindrical spectacles. Longer experience with wear of such contact lenses is needed, however the data are promising with regard to a new generation of contact lenses aimed at myopia control.
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