April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Reduction in the Rate of Progress of Myopia With a Contact Lens Designed to Reduce Relative Peripheral Hyperopia
B. A. Holden; P. Sankaridurg; P. Lazon de la Jara; E. L. Smith, III; X. Chen; J. Kwan; A. Martinez; A. Ho; J. Ge; The Vision CRC Myopia Control Study Group
Author Affiliations & Notes
  • B. A. Holden
    Institute for Eye Research, Sydney, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
  • P. Sankaridurg
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • P. Lazon de la Jara
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • E. L. Smith, III
    College of Optometry, University of Houston, Houston, Texas
  • X. Chen
    Zhongshan Ophthalmic Centre, Guangzhou, China
  • J. Kwan
    Institute for Eye Research, Sydney, Australia
  • A. Martinez
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • A. Ho
    Institute for Eye Research, Sydney, Australia
    Vision Cooperative Research Centre, Sydney, Australia
  • J. Ge
    Zhongshan Ophthalmic Centre, Guangzhou, China
  • The Vision CRC Myopia Control Study Group
    Institute for Eye Research, Sydney, Australia
  • Footnotes
    Commercial Relationships  B.A. Holden, Institute for Eye Research, E; US7025460;US20070296916, P; P. Sankaridurg, Institute for Eye Research, E; US20070296916, P; P. Lazon de la Jara, Institute for Eye Research, E; WO/2009/129528A1, P; E.L. Smith, III, US7025460;US20070296916, P; X. Chen, None; J. Kwan, Institute for Eye Research, E; A. Martinez, Institute for Eye Research, E; WO/2009/129528A1, P; A. Ho, Institute for Eye Research, E; US7025460;US20070296916, P; J. Ge, None.
  • Footnotes
    Support  Funded by Australian Government CRC Program, Institute for Eye Research and CIBA Vision grants.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2220. doi:
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      B. A. Holden, P. Sankaridurg, P. Lazon de la Jara, E. L. Smith, III, X. Chen, J. Kwan, A. Martinez, A. Ho, J. Ge, The Vision CRC Myopia Control Study Group; Reduction in the Rate of Progress of Myopia With a Contact Lens Designed to Reduce Relative Peripheral Hyperopia. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2220.

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Abstract

Purpose: : To determine if a silicone hydrogel contact lens designed to fully correct central vision but reduce relative peripheral hyperopia (AMCL) would reduce the rate of progress of myopia.

Methods: : Rates of progress of myopia over 6 months of Chinese children with baseline myopia between sphere -0.75 to -3.50D and cylinder ≤0.50D, and aged 7 to 14 yrs, wearing AMCL (n=65) were compared to children (n=50) wearing normal sphero-cylindrical spectacles (SPL). Change in spherical equivalent refractive error (SphE) measured with cycloplegic auto-refraction and axial length (AL) at 6 months were the outcome measures. Myopia progression between groups was compared using linear mixed models and if significant, post-hoc multiple comparisons with Bonferroni corrections were performed.

Results: : Progression of myopia with AMCL was significantly less, -0.26±0.25D, than with SPL,-0.60±0.29D (p<0.01). Similarly, AL increase was less with AMCL, 0.08±0.11mm, compared to SPL, 0.25±0.12mm (p<0.01). Upon adjusting for type of lens, parental myopia, gender, age and baseline SphE values, estimated progression in SphE was -0.29D with AMCL (standard error (SE) 0.04, confidence interval (CI) -0.36 to -0.21D) compared with -0.63D ( SE 0.04, CI -0.72 to -0.55D) for SPL and for AL, 0.10mm, (SE 0.02mm, CI 0.07 to 0.14mm) with AMCL compared with 0.25mm (SE 0.02, CI 0.22 to 0.29mm) with SPL.

Conclusions: : After 6 months of wear, progression of myopia with a contact lens designed to maintain clear central vision but reduce relative peripheral hyperopia was 54% less than that with standard sphero-cylindrical spectacles. Longer experience with wear of such contact lenses is needed, however the data are promising with regard to a new generation of contact lenses aimed at myopia control.

Clinical Trial: : www.chictr.org 00000029;00000232

Keywords: myopia • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • contact lens 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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