April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Wide-Field and High-Contrast Imaging of Retinal and Choroidal Vasculature by High-Sensitive Doppler Optical Coherence Angiography
Author Affiliations & Notes
  • S. Makita
    Computational Optics Group, Univ of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • M. Miura
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
    Dept of Ophthalmology, Tokyo Med Univ, Ibaraki Medical Center, Inashiki, Japan
  • M. Yamanari
    Computational Optics Group, Univ of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Y. Yasuno
    Computational Optics Group, Univ of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Footnotes
    Commercial Relationships  S. Makita, Topcon Corp., F; M. Miura, None; M. Yamanari, TOPCON, F; Y. Yasuno, TOPCON Corp., F.
  • Footnotes
    Support  Grant program of Japan Science Technology Agency
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2225. doi:https://doi.org/
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      S. Makita, M. Miura, M. Yamanari, Y. Yasuno; Wide-Field and High-Contrast Imaging of Retinal and Choroidal Vasculature by High-Sensitive Doppler Optical Coherence Angiography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2225. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To visualize retinal and choroidal vessels and abnormal vasculature non-invasively by high-sensitive Doppler optical coherence angiography.

 
Methods:
 

High-speed spectral-domain OCT with double probing beams is used. Doppler frequency shift is obtained from the phase shift between two OCT signals acquired by each probing beam at the same location, but the different time position. This system is operated at 27,000 axial scans per second. An imaging area of 7.7 × 7.7 mm was scanned within 5 seconds. The minimum detectable axial blood flow is 55 µm/s at signal-to-noise ratio of 15 dB. Three-dimensional blood flow distribution with slow blood flow velocity will be detected. High-sensitive Doppler optical coherence angiography (HS-DOCA) was performed for 10 eyes of 5 subjects without marked posterior abnormalities and 3 eyes of polypoidal choroidal vasculopathy (PCV). The retinal and choroidal vasculature was divided based on the location of the retinal pigment epithelium segmented by OCT images. En-face projection images of the retinal and choroidal blood flow distribution in PCV are compared with other modalities.

 
Results:
 

In 10 of the 10 eyes without abnormalities, major retinal vessels and narrow retinal arterioles were visualized in retinal en-face projections, and vasculature of small choroidal vessesls were observed in choroidal en-face projections. In 3 of the 3 eyes of PCV, vascular network was observed in choroidal en-face projections. In 3 of 3 eyes, the vascular patterns of these projections were corresponded to those in Indocyanine green angiography as shown in Figure.

 
Conclusions:
 

High-sensitive Doppler OCA can visualize vasculature of small retinal and choroidal vessels, and be used to detect abnormal vessels in PCV non-invasively.  

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • choroid: neovascularization • blood supply 
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