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M. Ebinuma, T. Kurihara, M. Omoto, K. Noda, S. Kubota, Y. Ozawa, S. Shimmura, S. Ishida, K. Tsubota; Yellow Intraocular Lens Implantation Prevents Light-Induced Retinal Damage in Mice. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2257.
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Although the inhibitory effect of yellow filter on light-induced retinal damage was already shown, there is no study reported on the effect of yellow intraocular lens (IOL) implanted after lens extraction, which mimics human post operative status. After establishing a novel model of IOL implantation in mice, we determined the effect of yellow IOL in comparison with colorless IOL.
Extra-capsular crystalline lens extraction was performed to 6-week-old BALB/c male mice. Ultraviolet (UV)-blocking colorless IOL or blue light- and UV-absorbing yellow IOL was implanted into lens capsule. IOL-implanted mice were exposed to 5,000 lux white light for 24 hours. Retinal damage was evaluated by TUNEL staining, outer nuclear layer (ONL) thickness measurement and electroretinography (ERG).
TUNEL-positive cells in yellow IOL-implanted mice were significantly (P < 0.05) reduced compared with colorless IOL-implanted mice. Compared to colorless IOL, yellow IOL implantation led to significant (P < 0.05) reduction of ONL thickness and ERG amplitude.
Yellow IOL implanted after lens extraction has protective effects against light-induced retinal damage.
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