April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Yellow Intraocular Lens Implantation Prevents Light-Induced Retinal Damage in Mice
M. Ebinuma; T. Kurihara; M. Omoto; K. Noda; S. Kubota; Y. Ozawa; S. Shimmura; S. Ishida; K. Tsubota
Author Affiliations & Notes
  • M. Ebinuma
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • T. Kurihara
    Ophthalmology,
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • M. Omoto
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology, Laboratory of Corneal Cell Biology, Tokyo, Japan
  • K. Noda
    Ophthalmology,
    Laboratory of Retinal Cell Biology, Tokyo, Japan
    Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • S. Kubota
    Ophthalmology,
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • Y. Ozawa
    Ophthalmology,
    Laboratory of Retinal Cell Biology, Tokyo, Japan
  • S. Shimmura
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology, Laboratory of Corneal Cell Biology, Tokyo, Japan
  • S. Ishida
    Ophthalmology,
    Laboratory of Retinal Cell Biology, Tokyo, Japan
    Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • K. Tsubota
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships  M. Ebinuma, None; T. Kurihara, research materials, F; M. Omoto, research materials, F; K. Noda, research materials, F; S. Kubota, None; Y. Ozawa, None; S. Shimmura, None; S. Ishida, None; K. Tsubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2257. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Yellow Intraocular Lens Implantation Prevents Light-Induced Retinal Damage in Mice
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      M. Ebinuma, T. Kurihara, M. Omoto, K. Noda, S. Kubota, Y. Ozawa, S. Shimmura, S. Ishida, K. Tsubota; Yellow Intraocular Lens Implantation Prevents Light-Induced Retinal Damage in Mice. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2257.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Although the inhibitory effect of yellow filter on light-induced retinal damage was already shown, there is no study reported on the effect of yellow intraocular lens (IOL) implanted after lens extraction, which mimics human post operative status. After establishing a novel model of IOL implantation in mice, we determined the effect of yellow IOL in comparison with colorless IOL.

Methods: : Extra-capsular crystalline lens extraction was performed to 6-week-old BALB/c male mice. Ultraviolet (UV)-blocking colorless IOL or blue light- and UV-absorbing yellow IOL was implanted into lens capsule. IOL-implanted mice were exposed to 5,000 lux white light for 24 hours. Retinal damage was evaluated by TUNEL staining, outer nuclear layer (ONL) thickness measurement and electroretinography (ERG).

Results: : TUNEL-positive cells in yellow IOL-implanted mice were significantly (P < 0.05) reduced compared with colorless IOL-implanted mice. Compared to colorless IOL, yellow IOL implantation led to significant (P < 0.05) reduction of ONL thickness and ERG amplitude.

Conclusions: : Yellow IOL implanted after lens extraction has protective effects against light-induced retinal damage.

Keywords: apoptosis/cell death • intraocular lens • photoreceptors 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept