April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Integrated Imaging of Reticular Pseudodrusen in Age-Related Macular Degeneration
Author Affiliations & Notes
  • L. Querques
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • G. Querques
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • D. Martinelli
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • N. Massamba
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • N. Leveziel
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • V. Letien
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • G. Coscas
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • G. Soubrane
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • E. Souied
    Department of Ophthalmology- Hopital Intercommunal de Créteil - Université Henri Mondor - Paris XII, Creteil, France
  • Footnotes
    Commercial Relationships  L. Querques, None; G. Querques, None; D. Martinelli, None; N. Massamba, None; N. Leveziel, None; V. Letien, None; G. Coscas, None; G. Soubrane, None; E. Souied, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2265. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      L. Querques, G. Querques, D. Martinelli, N. Massamba, N. Leveziel, V. Letien, G. Coscas, G. Soubrane, E. Souied; Integrated Imaging of Reticular Pseudodrusen in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2265.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To analyze the integrated imaging of age-reated macular degeneration patients with reticular pseudodrusen using confocal scanning laser ophthalmoscopy (cSLO) and eye-tracked Spectralis high-resolution spectral domain optical coherence tomography in a prospective observational cases series.

Methods: : Patients with reticular pseudodrusen were evaluated regarding fundus autofluorescence (FAF), infrared (IR) reflectance, and eye-tracked SD-OCT findings.

Results: : Forty-two eyes from 22 consecutive patients (12 female, 10 male; mean age 81.38 ± 6.47 years) were included for analysis. Best-corrected visual acuity ranged from 20/20 to 20/400. In 14 eyes the coincident diagnosis was late AMD. Four eyes from 3 patients with reticular pseudodrusen, showed coincident pseudovitelliform material within the macular area.FAF and IR reflectance, revealed a "target" aspect for the center of reticular pseudodrusen: an area of increased autofluorescence/reflectance surrounded by halos of reduced autofluorescence/reflectance. SD-OCT showed a well-defined round or triangular hyper-reflective deposit localized between, externally, the retinal pigment epithelium (RPE) layer, and, internally, the external limiting membrane (ELM) or the outer plexiform layer (OPL). Moreover, SD-OCT showed the loss of both outer segment (OS)/RPE interface, and inner segment (IS)/OS interface over the hyper-reflective lesions, as well as an abrupt interruption of both these 2 interfaces at the border of the hyper-reflective lesions.

Conclusions: : The peculiar "target" aspect of reticular pseudodrusen suggests the presence of central lipofuscin-like retinal deposits localized above the RPE. These findings give insights on other possible aspects of age-related retinal changes.

Keywords: age-related macular degeneration • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×