April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Reproducibility of Macular Thickness Measurements Using Cirrus Spectral Domain Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration
Author Affiliations & Notes
  • F. Scarinci
    Ophthalmology, Fondazione GB Bietti-IRCCS, Roma, Italy
  • M. Parravano
    Ophthalmology, Fondazione GB Bietti-IRCCS, Roma, Italy
  • F. Oddone
    Ophthalmology, Fondazione GB Bietti-IRCCS, Roma, Italy
  • B. Boccassini
    Ophthalmology, Fondazione GB Bietti-IRCCS, Roma, Italy
  • F. Menchini
    Ophthalmology, University of Udine, Azienda Ospedaliero-Universitaria di Udine, Udine, Italy
  • M. Varano
    Ophthalmology, Fondazione GB Bietti-IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships  F. Scarinci, None; M. Parravano, None; F. Oddone, None; B. Boccassini, None; F. Menchini, None; M. Varano, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2272. doi:
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      F. Scarinci, M. Parravano, F. Oddone, B. Boccassini, F. Menchini, M. Varano; Reproducibility of Macular Thickness Measurements Using Cirrus Spectral Domain Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2272.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : to assess test-retest variability of central and sectorial macular thickness measurements obtained by Cirrus HD-OCT in neovascular age related macular degeneration (nAMD).

Methods: : Macular thickness measurements of 9 standard ETDRS subfields were obtained and analyzed. To assess the repeatability of macular thickness of Cirrus HD-OCT the intrasession within subject standard deviation (Sw) and coefficient of repeatibility (CR) were assessed before and after excluding eyes with retinal segmentation errors

Results: : A total of 51 nAMD eyes of 49 consecutive patients were included in the study. The CR for the central macular subfield was 41.6 µm (12.4%) and ranged from 11.8 µm (4.0%) for the outer nasal to 40.7 µm (11.5%) for the inner nasal subfields. In a secondary analysis eyes affected by erroneous detection of inner and outer retinal boundaries (6/51, 11.8%) were excluded. The revised CR for the central macular subfield was 26.0 µm (7.9%) and ranged from 10.1 µm (3.8%) for the outer superior to 29.4 µm (8.3%) for the inner nasal subfields. The CR change for the central macular subfield was 36.3%

Conclusions: : Test-retest variability of Cirrus HD-OCT is overall good for central and sectorial macular subfields with a low incidence of scan artifacts, supporting its use in the clinical trials setting.

Keywords: age-related macular degeneration • imaging/image analysis: clinical • choroid: neovascularization 
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