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F. Scarinci, M. Parravano, F. Oddone, B. Boccassini, F. Menchini, M. Varano; Reproducibility of Macular Thickness Measurements Using Cirrus Spectral Domain Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2272.
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to assess test-retest variability of central and sectorial macular thickness measurements obtained by Cirrus HD-OCT in neovascular age related macular degeneration (nAMD).
Macular thickness measurements of 9 standard ETDRS subfields were obtained and analyzed. To assess the repeatability of macular thickness of Cirrus HD-OCT the intrasession within subject standard deviation (Sw) and coefficient of repeatibility (CR) were assessed before and after excluding eyes with retinal segmentation errors
A total of 51 nAMD eyes of 49 consecutive patients were included in the study. The CR for the central macular subfield was 41.6 µm (12.4%) and ranged from 11.8 µm (4.0%) for the outer nasal to 40.7 µm (11.5%) for the inner nasal subfields. In a secondary analysis eyes affected by erroneous detection of inner and outer retinal boundaries (6/51, 11.8%) were excluded. The revised CR for the central macular subfield was 26.0 µm (7.9%) and ranged from 10.1 µm (3.8%) for the outer superior to 29.4 µm (8.3%) for the inner nasal subfields. The CR change for the central macular subfield was 36.3%
Test-retest variability of Cirrus HD-OCT is overall good for central and sectorial macular subfields with a low incidence of scan artifacts, supporting its use in the clinical trials setting.
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