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R. A. Costa, D. Calucci, D. C. Ferrara, J. L. Orefice, R. Jorge, F. Orefice; The New Highly Reflective Layer on High-Resolution High-Speed Optical Coherence Tomography at the Macula: Verhoeff Membrane or Photoreceptors’ Outer Segments?. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2305.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the outer retina aspect of the human macula on high-resolution high-speed optical coherence tomography (HR/HS-OCT).
This was a retrospective study involving patients with established choroidal and retinal diseases such as central serous chorioretinopathy, early and late age-related maculopathy and idiopathic macular hole, as well as a subset of eyes with normal macular architecture imaged with HR/HS-OCT between January 2008 and July 2009 at a single center in Brazil. The HR/HS-OCT data were qualitatively assessed in all participants, and built-in software measurement tools were utilized for quantitative analysis.
HR/HS-OCT data from one hundred and eight eyes were evaluated. Three parallel, linear highly reflective layers (HRL) were seen at the level of the outer retina in normal macular regions. In normal conditions the thickness of the outer HRL throughout the macula ranged from 15 to 22 micrometers whereas the thickness of the reflective complex composed by outer and middle HRLs ranged from 32 to 45 micrometers. Disappearance of the inner HRL and of the middle HRL with maintenance of the outer HRL was seen in the presence of eye conditions affecting the external retinal layers. The point-by-point multimodal correlation of the HR/HS-OCT findings with the expected clinical and angiographic features on eyes presenting specific macular conditions pointed toward a retinal pigment epithelium-retina interface occurring between the middle HRL and outer HRL.
Qualitative and quantitative evaluation of tomographic data in subjects with and without macular diseases suggests that the new HRL revealed with the advent of HR/HS-OCT corresponds most likely to reflective signals from photoreceptors’ outer segments.
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