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M. Hanebuchi, J. Sasaki, N. Shibata, Y. Fujisaka, Y. Yamada, H. Mukai, S. Oshima; Adaptive Optics Scanning Laser Ophthalmoscopy for Imaging Retina Using a Single Liquid Crystal Spatial Light Modulator. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2307.
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© ARVO (1962-2015); The Authors (2016-present)
To develop an adaptive optics confocal scanning laser ophthalmoscope(AO-SLO) system for high resoluion retinal imaging which uses a single liquid crystal spatial light modulator(LC-SLM) as a wavefront corrector and is combined with a standard resolution confocal scannig laser ophthalmoscope(SLO) capable of acquiring wide field of view retinal images and across which the retinal region to be imaged with AO-SLO can be shifted rapidly
We developed an AO-SLO system using one LC-SLM device as a wavefront corrector. The accumulated astigmatism resulting from the sequence of the off-axis reflection at concave mirrors is cancelled by introducing a counter astigmatism, which enables the RMS wavefront error intrinsic to the optical system to be lower than 0.1wave at the subject's pupil without AO correction. It has a badal system to correct subjects' defocus and the residual astigmatism and high-order aberration including subjects' eye and the optics is corrected by LC-SLM. The AO-SLO retinal images are acquired at 10 frames per second and its field of view is 1.5degree by 1.5degree. It is combined with a standard resolution SLO for a large field of view retinal imaging across which the retinal region to be observed with AO-SLO can be shifted by an operator's mouse-operation. The light source is 840nm superluminescent diode with its bandwidth of 50nm for high resolution imaging, 780nm laser diode for wavefront sensing and 910nm superluminescent diode for wide field imaging. The power into the eye is 210 µW, 70 µW, 350 µW, respectively.
Nearly diffraction limited resolution was confirmed experimentally using a model eye with resolution chart at its back surface and photoreceptors of healthy eyes have been observed with this AO-SLO system.
High resolution AO-SLO retinal imaging system was realized with a single LC-SLM based adaptive optics. It is combined with a standard resolution SLO for wide field of view imaging across which multiple views of the AO-SLO retinal imaging can be easily obtained by changing the angle of the beam at the pupil.
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