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D. A. Valenti; Neurologic Disease: Use of Frequency Doubling Technology. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2334.
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Pathologies affecting neurological processing are hypothesized to have an impact on the visual system at a higher rate than the general population. In addition to traditional Snellen acuities, the threshold strategy test in the Frequency Doubling Technology was used as a screening tool to evaluate patients with an identified disease of the neurological system and age matched controls with no neurological diagnosis.
Patients and family members presenting for care in neurology clinics affiliated with Boston University were invited to participate in a vision screening that included a brief visual history, distance acuities and FDT. The FDT is believed to have the capacity to isolate retinal ganglion cells in the magnocellular pathway by utilizing a low spatial frequency sinusoidal grating (<1 cyc/degree) that undergoes a high temporal frequency counter phase flicker at 25 Hz or greater. Back lit flashed images are viewed on a fixed, flat, shielded screen in front of a stationary subject. The patient perceives the targets as small, striped square-shaped areas in either central or peripheral vision.
Fifty nine of the patients scheduled for care in the neurology clinic were tested and thirty four adults accompanying a patient scheduled for care were tested. There was a higher rate of failure among those patients with a neurological diagnosis than among the control participants.
Based on those patients presenting for care, there is higher rate of visual deficits warranting further examination in patients diagnosed with a neurological disease compared to an age matched population not identified as having a diagnosis of a neurological disease.
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