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G. Rebolleda, A. Garcia-Garcia, H.-R. Won Kim, F. J. Muñoz-Negrete; Comparison of Retinal Nerve Fiber Layer Thickness Measured by Time Domain and Spectral Domain Optical Coherence Tomography in Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2336.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the agreement between retinal nerve fiber layer (RNFL) thickness measurements from Stratus time domain optical coherence tomography (OCT) and Cirrus spectral domain OCT in subjects with optic neuritis.
22 patients previously diagnosed of unilateral optic neuritis were imaged by two trained operators using the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) at the same visit. The RNFL thicknesses as measured by both devices were compared (Wilcoxon test). The relationship between RNFL thickness measurements of the 2 OCTs (overall and by quadrants) were evaluated using Intraclass CorrelationCoefficient (ICC) and Bland-Altman plots. Differences of measurements between both technologies comparing eyes having optic neuritis (study eye group) and fellow eyes (fellow eye group) were assessed using the U-Mann-Whitney test.
Using Stratus OCT, the average RNFL was 86.3 µ and 102.9 µ in the study and in the fellow eye group respectively. For Cirrus OCT, the average RNFL were 81 µ for the study eye group and 94.9 µ for the fellow eye group. In the study eye group the measurements in superior, inferior, temporal and nasal quadrants were 109.9, 109.2, 59.2 and 66.9 µ for the superior, inferior, temporal and nasal quadrants, respectively using Stratus OCT and 96.2, 100.9, 57.7 and 66.9 µ respectively using Cirrus OCT. In the fellow eye group RNFL thicknesses in superior, inferior, temporal and nasal quadrants were 128.7, 132.3, 69.9 and 81 µ for the superior, inferior, temporal and nasal quadrants, respectively using Stratus OCT and 116.4, 125.4, 66.4 and 73.1 µ respectively using Cirrus OCT. RNFL thicknesses were significantly lower in the study eye group compared with fellow eye group by the Cirrus and Stratus OCT. Stratus-Cirrus differences were statistically significant in the overall measurement in both groups and in the superior, nasal and inferior quadrants in the fellow eye group (P < 0.05). Average RNFL thickness as determined by the 2 OCT machines was well correlated (ICC was 0.855 and 0.744 in the study eye group and fellow eye group respectively), with the highest correlation in the superior and nasal quadrants.
Cirrus and Stratus OCT RNFL thickness measurements are well correlated in patients with optic neuritis. However, clinicians should be aware that measurements are generally higher with Stratus than with Cirrus so, these two instruments should not be considered interchangeable in the case of a patient who undergoes 2 different types of OCT scan for longitudinal follow-up.
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