Purchase this article with an account.
M. Carbonelli, G. Savini, P. Barboni; Retinal Nerve Fiber Layer Thickness Changes According to Axial Length in Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2340.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (OCT) and axial length in a sample of healthy eyes.
RNFL thickness was measured by CirrusTM HD-OCT in 39 eyes of 39 healthy subjects whose axial length was assessed by ultrasound biometry.
Axial length ranged between 20.80 and 22.5mm in 11 eyes, between 22.51 and 25.0mm in 11 eyes and between 25.01 and 28.85 mm in 17 eyes. Analysis of variance showed a statistical difference (p=0.0016) among the 3 groups, whose average 360° RNFL thickness was respectively 102.63±12.33, 93.63±6.36 and 87.41±10.21 microns. Linear regression disclosed a statistically significant relationship between axial length and average 360° RNFL thickness (r=-0.6147, p<0.0001), superior quadrant (r=-0.4822, p=0.0019), nasal quadrant (r=-0.5918, p<0.0001) and inferior quadrant (r=-0.6409, p<0,0001), but not temporal quadrant (r=-0.07493, p>0.05).
Our data confirmed previous results obtained by time-domain OCT, as RNFL thickness measured by spectral-domain OCT is influenced by axial length. This phenomenon should be considered when interpreting a glaucoma suspect's Cirrus HD-OCT measurements compared with the normative database.
This PDF is available to Subscribers Only