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U. Mian, A. Shrivastava, K. Novoa, J. S. Schultz; To Evaluate the Effect of Developing a Partial Vitreous Separation, at the Optic Nerve, on Retinal Nerve Fiber Layer Thickness (RNFL) as Measured by OCT. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2342.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of developing a partial vitreous separation, at the optic nerve, on peripapillary retinal nerve fiber layer thickness (RNFL) as measured by time domain OCT.
The OCT database for patients followed as glaucoma suspects at Montefiore Medical Center was searched for the developement of a partial PVD (pPVD) surrounding the optic nerve. Included subjects had a partial vitreous separation at the optic nerve not seen in previous scans. Twenty-nine patients were identified. Nine of twenty-nine patients were included, based on good quality scans and clearly visible vitreous separation.
Average RNFL thickening before partial PVD (no PVD) was 99.00 microns which increased to 104.44 microns (p<0.006) with the development of pPVD. One subject measured the same RNFL thickness while the rest (n=8) had an increase in the RNFL thickness with the development of a pPVD. No subjects demonstrated decreased RNFL thickness with the development of a pPVD.
Development of partial vitreous separation increases the thickness of the peripapillary RNFL. Traction to the RNFL by the partially separated vitreous could be an explanation for this observation. Presence of a pPVD should be taken into account when interpreting RNFL thickness at the optic nerve.
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