April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Ophthalmic Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis and Relation to SCORTEN
Author Affiliations & Notes
  • M. E. Morales
    Ophthalmology,
    University of Texas Southwestern Medical Center, Dallas, Texas
  • G. F. Purdue
    Surgery,
    University of Texas Southwestern Medical Center, Dallas, Texas
  • S. M. Verity
    Ophthalmology,
    University of Texas Southwestern Medical Center, Dallas, Texas
  • B. D. Arnoldo
    Surgery,
    University of Texas Southwestern Medical Center, Dallas, Texas
  • P. H. Blomquist
    Ophthalmology,
    University of Texas Southwestern Medical Center, Dallas, Texas
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2385. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. E. Morales, G. F. Purdue, S. M. Verity, B. D. Arnoldo, P. H. Blomquist; Ophthalmic Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis and Relation to SCORTEN. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2385.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To evaluate the severity of ocular involvement of patients with Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap, and to investigate the relationship of the SCORTEN (severity of illness score in SJS and TEN patients, which predicts mortality in the acute setting) with eye disease in this patient population.

 
Methods:
 

This is a retrospective observational case series of 82 patients with a diagnosis of SJS, SJS/TEN overlap, or TEN. Charts of all patients admitted to the Parkland Memorial Hospital Burn Center with a preliminary diagnosis of SJS, SJS/TEN overlap, or TEN between 1998 and 2008 were reviewed. Patients were included for study if they met clinical criteria, had positive diagnostic skin biopsy, and had dermatologic and ophthalmologic consultations. Ocular manifestations were classified as mild, moderate or severe. Admission data were used to calculate the SCORTEN. The main outcome measures were the severity of ocular involvement with respect to diagnosis and SCORTEN.

 
Results:
 

Overall, 84% of patients had ocular involvement (71% SJS, 90% TEN, 100% SJS/TEN overlap). There was no difference in the severity of acute ocular complications among groups. While the SCORTEN value did correlate well with mortality rate (correlation coefficient 0.97, P= 0.005), there was no correlation between the SCORTEN value and severity of eye involvement in the acute setting. There was also no association of any individual diagnosis of SJS/Overlap/TEN with the severity of eye involvement, although eye findings are more common in TEN (P= 0.03).

 
Conclusions:
 

Ocular damage in the acute setting was more frequent in patients with epidermal detachment > 10% of the total body surface area. The SCORTEN value did not correlate with the severity of eye involvement in the acute setting.  

 
Keywords: clinical (human) or epidemiologic studies: outcomes/complications • drug toxicity/drug effects • cornea: clinical science 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×