April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Oral Ivermectin in Patients With Refractory Chronic Blepharitis Associated With Demodex Folliculorum
Author Affiliations & Notes
  • F. G. Holzchuh
    Departamento de Oftalmologia,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
    Clinica Oftalmologica do HCFMUSP, Ambulatorio de Superficie Ocular do HCFMUSP, Sao Paulo, Brazil
  • R. Y. Hida
    Ophthalmology, Univ de Sao Paulo/Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • M. B. V. Albers
    Departamento de Oftalmologia,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • D. T. Q. Barbosa
    Departamento de Oftalmologia,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • B. K. Moscovici
    Departamento de Oftalmologia,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • B. B. Chiacchio
    Clinica Oftalmologica do HCFMUSP, Ambulatorio de Superficie Ocular do HCFMUSP, Sao Paulo, Brazil
  • R. M. Santo
    Ophthalmology and Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
  • N. Kara-José
    Clinica Oftalmologica do HCFMUSP, Ambulatorio de Superficie Ocular do HCFMUSP, Sao Paulo, Brazil
  • N. Holzchuh
    Departamento de Oftalmologia,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • R. Holzchuh
    Ophthalmology,
    Santa Casa de Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  F.G. Holzchuh, None; R.Y. Hida, None; M.B.V. Albers, None; D.T.Q. Barbosa, None; B.K. Moscovici, None; B.B. Chiacchio, None; R.M. Santo, None; N. Kara-José, None; N. Holzchuh, None; R. Holzchuh, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2388. doi:https://doi.org/
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      F. G. Holzchuh, R. Y. Hida, M. B. V. Albers, D. T. Q. Barbosa, B. K. Moscovici, B. B. Chiacchio, R. M. Santo, N. Kara-José, N. Holzchuh, R. Holzchuh; Oral Ivermectin in Patients With Refractory Chronic Blepharitis Associated With Demodex Folliculorum. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2388. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the efficacy of oral ivermectin in patients with refractory chronic blepharitis, in the presence of the Demodex folliculorum.

Methods: : Prospective and experimental study involving 13 patients (26 eyes) (50.4 ± 21.0 years old) with refractory chronic blepharitis in the presence of Demodex folliculorum in the eyelash were enclosed. All the patients of this study were analyzed 1 day before and 30 days after the treatment with oral ivermectin. Lacrimal meniscus height measurement, Tear break-up-time, fluorescein and rose bengal staining score, Schirmer I test and the quantification of Demodex in the removed eyelashes were performed. Patients were treated with one dose 200µg/kg of oral ivermectin. The treatment was repeated after 7 days.

Results: : Improvement of the average lacrimal meniscus height (p=0,0397), tear break-up-time (p=0,0018) and Schirmer I test (p=0,0005) was observed after the treatment with ivermectin. Fluorescein and rose bengal staining score has not improved. Reduction of the average Demodex (eyelashes of the upper/lower eyelid margin) was observed after the treatment with ivermectin (p=0,0006).

Conclusions: : Ivermectin could be a useful tool for the reduction of the Demodex folliculorum in eyelashes of the patients with chronic refractory blepharitis. Improvement of the average number of parasites found in the eyelashes, lacrimal meniscus height, tear break-up-time and Schirmer I test was observed after 30 days of treatment with ivermectin.

Clinical Trial: : www.hcnet.usp.br/adm/dc/cappesq/ Number 0688/09

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • anterior segment • eyelid 
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