April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Effects of 0.5% Anisodamine Eye Drop on Pupil Size and Accommodation in Children
Author Affiliations & Notes
  • Z. Chen
    Ophthalmology and Visual Science, Fudan University EENT Hospital, Shanghai, China
  • T. Li
    Ophthalmology and Visual Science, Fudan University EENT Hospital, Shanghai, China
  • X. T. Zhou
    Ophthalmology and Visual Science, Fudan University EENT Hospital, Shanghai, China
  • R. Y. Chu
    Ophthalmology and Visual Science, Fudan University EENT Hospital, Shanghai, China
  • Footnotes
    Commercial Relationships  Z. Chen, None; T. Li, None; X.T. Zhou, None; R.Y. Chu, None.
  • Footnotes
    Support  Science and Technology Commission of Shanghai Municipality Grant 09DZ1906700
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2458. doi:
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    • Get Citation

      Z. Chen, T. Li, X. T. Zhou, R. Y. Chu; Effects of 0.5% Anisodamine Eye Drop on Pupil Size and Accommodation in Children. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2458.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the effect of a new non-selective muscarinic antagonist, 0.5% anisodamine eye drop on pupil size and accommodative response in children.

Methods: : 20 healthy myopic children aged between 9 and 12 were enrolled in the study. They were given two successive drops of 0.5% anisodamine in one eye. Scotopic pupil sizes of both eyes were evaluated with an infrared open-field autorefractor before and 10, 20, 30, 45, 60, 90, 120, 180, 240, 300, 360 minutes after treatment. Accommodative responses to the Maltese cross at 50cm, 33cm and 20cm were also measured. Statistical analysis used repeated measurements of ANOVA.

Results: : Pupil of the treated eye experienced a 45 minutes’ diminishing then an enlarging process, which reached a peak size of approximately 0.75mm larger than baseline at 2 hours followed by a recovering process. The contralateral eye went through a similar diminishing and a recovering process. Accommodative response didn’t change at any time or distance during the procedure for both eyes.

Conclusions: : As a non-selective muscarinic antagonist which has been approved by sFDA and commercially available in China, 0.5% anisodamine eye drop is a mild and safe solution, which maybe potentially used for myopic control in children and adolescents. Counterintuitively, the treated eyes went through a more complex procedure rather than sheerly mydriasis and cycloplegia.

Keywords: myopia • accommodation • pupil 
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