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Z. Chen, T. Li, X. T. Zhou, R. Y. Chu; Effects of 0.5% Anisodamine Eye Drop on Pupil Size and Accommodation in Children. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2458.
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To investigate the effect of a new non-selective muscarinic antagonist, 0.5% anisodamine eye drop on pupil size and accommodative response in children.
20 healthy myopic children aged between 9 and 12 were enrolled in the study. They were given two successive drops of 0.5% anisodamine in one eye. Scotopic pupil sizes of both eyes were evaluated with an infrared open-field autorefractor before and 10, 20, 30, 45, 60, 90, 120, 180, 240, 300, 360 minutes after treatment. Accommodative responses to the Maltese cross at 50cm, 33cm and 20cm were also measured. Statistical analysis used repeated measurements of ANOVA.
Pupil of the treated eye experienced a 45 minutes’ diminishing then an enlarging process, which reached a peak size of approximately 0.75mm larger than baseline at 2 hours followed by a recovering process. The contralateral eye went through a similar diminishing and a recovering process. Accommodative response didn’t change at any time or distance during the procedure for both eyes.
As a non-selective muscarinic antagonist which has been approved by sFDA and commercially available in China, 0.5% anisodamine eye drop is a mild and safe solution, which maybe potentially used for myopic control in children and adolescents. Counterintuitively, the treated eyes went through a more complex procedure rather than sheerly mydriasis and cycloplegia.
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