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T. Fukami, T. Sugawara, S. Yamamoto; Characteristics of Photopic Oscillatory Potentials Elicited by Long Duration Stimuli. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2463.
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© ARVO (1962-2015); The Authors (2016-present)
It has been reported that the photopic oscillatory potential (pOP) on the ascending limb of the photopic b-wave become larger with longer stimulus durations. The purpose of this study was to determine the characteristics of the pOPs elicited by stimulus durations longer than the ISCEV standard stimulus duration. A lower cutoff frequency was used to study the slower pOPs.
Photopic ERGs were elicited by white-on-white (W/W) stimuli using a contact lens electrode with built-in LEDs. We measured the pOPs and also the photopic negative responses (PhNRs) and the i-waves (off component) from the same responses. We elicited the photopic ERGs after 10 min of light adaptation with stimulus durations of 3, 5, 10, 16, and 30 ms, and recorded the responses with 1 and 100 Hz low cutoff filters. Ten normal volunteers (controls), 5 patients with simple diabetic retinopathy (DR), and 5 patients with unilateral optic atrophy (OA) were studied.
The pOPs were not distinct with 3 and 10 ms stimulus durations, but with 16 or 30 ms stimulus durations, the pOPs were very distinct. With the 16 ms stimulus duration, the b-wave overlapped the largest pOP, but with the 100 Hz low cutoff filter, the overlapping of the b-wave was not present and the pOP was larger than that with the 30 ms stimulus duration. Thus, the 16 ms stimulus duration was the best to record the pOPs with the PhNR and i-wave. There were six pOPs; pOP 1 to pOP 6 were recorded in the controls, and pOP1, 2, and 3 were significantly reduced in DR. pOP5 and 6 and the PhNR amplitude were significantly reduced in OA compared to the average of the controls.
Our findings suggest that 16 ms duration stimuli were the best to elicit large and distinct pOPs. The selective loss of different pOPs in different diseases suggest that they probably originate from different retinal neurons.
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