April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Prevalence of Posterior Subcapsular Cataracts in Volunteer Cytapheresis Donors
Author Affiliations & Notes
  • S. Vitale
    Div Epidemiol & Clinical Applications,
    National Eye Inst/NIH, Bethesda, Maryland
  • J. A. Clayton
    National Eye Inst/NIH, Bethesda, Maryland
    Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland
  • J. Kim
    The Emmes Corporation, Rockville, Maryland
  • C. Conry-Cantilena
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
  • P. Byrne
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
  • G. F. Reed
    Div Epidemiol & Clinical Applications,
    National Eye Inst/NIH, Bethesda, Maryland
  • S. F. Leitman
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
  • Footnotes
    Commercial Relationships  S. Vitale, None; J.A. Clayton, None; J. Kim, None; C. Conry-Cantilena, None; P. Byrne, None; G.F. Reed, None; S.F. Leitman, None.
  • Footnotes
    Support  National Eye Institute and the Department of Transfusion Medicine, National Institutes of Health
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2510. doi:
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      S. Vitale, J. A. Clayton, J. Kim, C. Conry-Cantilena, P. Byrne, G. F. Reed, S. F. Leitman; Prevalence of Posterior Subcapsular Cataracts in Volunteer Cytapheresis Donors. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2510.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the possible association of granulocyte apheresis donation with posterior subcapsular cataract (PSC) in a case-control study.

Methods: : We recruited 100 granulocyte donors (≥ 4 granulocyte donations; any number of platelet donations) and 100 age-sex-matched platelet-only donors to examine the risk of posterior subcapsular cataract (PSC). Granulocyte donors received dexamethasone 8 mg orally prior to donation. PSC was assessed by a masked ophthalmologist and by masked reading center lens photograph gradings (using the AREDS lens grading system and based on % opacification within the central 5 mm), or by medical record documentation of PSC as the reason for cataract extraction.

Results: : Granulocyte and platelet donors did not differ significantly with respect to age, gender, race, history of smoking, alcohol consumption, non-donation-related steroid exposure history, or other known PSC risk factors. 14 eyes of 10 granulocyte donors and 5 eyes of 4 platelet donors had PSC. After adjusting for potential confounders (age, history of ocular surgery or trauma, gender), granulocyte donors were more likely to have PSC than were platelet-only donors, although the odds ratio (OR) did not reach statistical significance (OR = 3.08, p = 0.08). Compared with platelet donors (4/100 with PSC), risk of PSC increased with number of granulocyte donations: 4-9 donations, 8.6% (OR = 2.25; p = 0.30); 10-19 donations, 9.5% (OR = 2.53; p = 0.21); and ≥ 20 donations, 13.0% (OR = 3.60; p = 0.11) (p = 0.06 for trend). Excluding eyes with a history of cataract extraction for PSC, 2.0% of platelet donors had PSC and the risk of PSC increased with number of granulocyte donations: 4-9 donations, 5.9% (OR = 4.45, p = 0.15); 10-19 donations, 4.8% (OR = 2.44, p = 0.37); and ≥ 20 donations, 13.0% (OR = 11.77, p=0.009), respectively (p = 0.04 for trend).

Conclusions: : We did not demonstrate a statistically significant increased risk of PSC associated with granulocyte donation in healthy apheresis donors. However, although this makes a large risk unlikely, we can not rule out a small to moderate risk and there is biologic plausibility that the steroid administration associated with granulocyte donation could be associated with PSC formation. A larger study is necessary to precisely define the extent of the increased risk. Frequent granulocyte donors should consider regular eye examinations.

Keywords: cataract • clinical (human) or epidemiologic studies: risk factor assessment 
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