Purchase this article with an account.
D. Goldblum, S. A. Fraenkl, J. Muser, R. Groell, G. Reinhard, J. Flammer; Plasma Citrate Levels as a Biomarker for Glaucoma Diagnosis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2669.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine plasma citrate levels in glaucoma patients.
Plasma and urine citrate and creatinine levels were determined in 6 glaucoma patients and 6 matched controls by ion chromatography and the citrate fractional excretion calculated.
The mean citrate and creatinine concentrations (µmol/L) were (table).
Significant lower plasma citrate concentrations were found in glaucoma patients whereas the citrate fractional excretion was not different.
Glaucoma might be a mitochondria associated disease. Since citrate is a major component in mitochondrial metabolism its determination in plasma might serve as a biomarker.
This PDF is available to Subscribers Only