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O. Gurses; The Effect of Serum Lipids and Glycosylated Hemoglobin on Short-Term and Long-Term Fluctuations in Intraocular Pressure of Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2674.
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To investigate the correlation of short-term (SF) and long-term fluctuations (LF) in intraocular pressure (IOP) with serum lipids and glycosylated hemoglobin (HbA1c) of healthy subjects.
This study is a retrospective randomized clinical trial involving 112 eyes of 56 healthy subjects who have refractive errors or early age-related lens changes. IOP measurements were obtained from both eyes of each subject by using Goldmann applanation tonometer at 5 different time points during the day for a consecutive 5-day period. SF in IOP was calculated by finding the difference of peak-trough IOP values measured during the day, and LF was calculated by finding the difference of peak- trough values in IOP during the consecutive 5-day period. Blood work-up for total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) cholesterol, triglyceride (TG) and HbA1c were obtained on the same day of admission from each subject. The mean(SD) values of average SF and average LF in IOP were correlated with the mean(SD) serum levels of total cholesterol, HDL, LDL and VLDL cholesterol, TG and HbA1c. Paired t-test was used for paired samples correlations. p < or = 0.05 was considered as statistically significant.
Statistically significant correlations of the mean(SD) of HbA1c with the mean(SD) of average SF (paired t-test, p= 0.001), and the mean(SD) of average LF were found (paired t-test, p = 0.001).
HbA1c was considered as a significant parameter affecting SF and LF in IOP of healthy subjects.
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