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D. G. Mikropoulos, A. I. Economou, K. Kaltsos, K. Boboridis, A. T. Dimopoulos, I. Georgiadou, M. B. Nasr, N. Ziakas, A. G. P. Konstas; Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Primary Open-Angle Glaucoma and Ocular Hypertention. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2676.
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To compare the central corneal thickness (CCT) measurement in patients with exfoliation syndrome (XFS), exfoliative glaucoma, (XFG) primary open-angle glaucoma (POAG), ocular hypertension (OHT) and normal controls and to evaluate the value of CCT in the early diagnosis of glaucoma.
Prospective study in progress. Consecutive Greek patients with XFS, XFG, POAG undergo a comprehensive ophthalmic exam which includes 2 separate CCT measurements over 2 different examinations at the same time of the day (10:00 am). The CCT values obtained are correlated with a number of other glaucoma parameters.
Data are presented herein from the first 525 consecutively examined patients. Patients with XFG demonstrated a significantly lower CCT than normal controls (528.9 vs 547.5 µ); (P=0.001). Patients with XFS also exhibited significantly lower CCT (525.1 µ) than normal controls (P=0.012), whereas those with POAG (539,1 µ) did not differ from normal controls (P=0.378). On the other hand, patients with OHT showed a significantly thicker cornea (561.1 µ) compared to normal subjects (P=0.021)
A thinner cornea may represent a specific attribute and an additional risk factor for patients with XFG. Evaluation of CCT is an important exam in the management of all patients with exfoliation.
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