April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Primary Open-Angle Glaucoma and Ocular Hypertention
Author Affiliations & Notes
  • D. G. Mikropoulos
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • A. I. Economou
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • K. Kaltsos
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • K. Boboridis
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • A. T. Dimopoulos
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • I. Georgiadou
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • M. B. Nasr
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • N. Ziakas
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • A. G. P. Konstas
    1st University Dept of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships  D.G. Mikropoulos, Alcon, Allergan, R; A.I. Economou, None; K. Kaltsos, Allergan, R; K. Boboridis, None; A.T. Dimopoulos, None; I. Georgiadou, None; M.B. Nasr, None; N. Ziakas, None; A.G.P. Konstas, Alcon, Allergan, Merck, Pfizer, F; Alcon, Allergan, Merck, Pfizer, R.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2676. doi:
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      D. G. Mikropoulos, A. I. Economou, K. Kaltsos, K. Boboridis, A. T. Dimopoulos, I. Georgiadou, M. B. Nasr, N. Ziakas, A. G. P. Konstas; Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Primary Open-Angle Glaucoma and Ocular Hypertention. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2676.

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Abstract

Purpose: : To compare the central corneal thickness (CCT) measurement in patients with exfoliation syndrome (XFS), exfoliative glaucoma, (XFG) primary open-angle glaucoma (POAG), ocular hypertension (OHT) and normal controls and to evaluate the value of CCT in the early diagnosis of glaucoma.

Methods: : Prospective study in progress. Consecutive Greek patients with XFS, XFG, POAG undergo a comprehensive ophthalmic exam which includes 2 separate CCT measurements over 2 different examinations at the same time of the day (10:00 am). The CCT values obtained are correlated with a number of other glaucoma parameters.

Results: : Data are presented herein from the first 525 consecutively examined patients. Patients with XFG demonstrated a significantly lower CCT than normal controls (528.9 vs 547.5 µ); (P=0.001). Patients with XFS also exhibited significantly lower CCT (525.1 µ) than normal controls (P=0.012), whereas those with POAG (539,1 µ) did not differ from normal controls (P=0.378). On the other hand, patients with OHT showed a significantly thicker cornea (561.1 µ) compared to normal subjects (P=0.021)

Conclusions: : A thinner cornea may represent a specific attribute and an additional risk factor for patients with XFG. Evaluation of CCT is an important exam in the management of all patients with exfoliation.

Clinical Trial: : www.clinicaltrials.gov NCT01023997

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • cornea: clinical science 
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