April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Exfoliation Syndrome, Intraocular Pressure and Disc Hemorrhage
S. M. Fernando; C. G. V. De Moraes; C. C. Teng; C. Tello; R. Ritch; J. M. Liebmann
Author Affiliations & Notes
  • S. M. Fernando
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York University School of Medicine, New York, New York
  • C. G. V. De Moraes
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York University School of Medicine, New York, New York
  • C. C. Teng
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York University School of Medicine, New York, New York
  • C. Tello
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    New York Medical College, Valhalla, New York
  • R. Ritch
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    New York Medical College, Valhalla, New York
  • J. M. Liebmann
    Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York University School of Medicine, New York, New York
  • Footnotes
    Commercial Relationships  S.M. Fernando, None; C.G.V. De Moraes, None; C.C. Teng, None; C. Tello, Diopsys, Inc., F; Alcon Laboratories, Inc., R; Allergan, Inc., R; R. Ritch, Carl Zeiss Meditec, Inc., F; Diopsys, Inc., F; Heidelberg Engineering, GmBH, F; Topcon, Inc., F; Alcon Laboratories, Inc., C; Allergan, Inc., C; Danube Pharmaceuticals, Inc., C; Pfizer Ophthalmics, Inc., C; J.M. Liebmann, Carl Zeiss Meditec, Inc., F; Diopsys, Inc., F; Heidelberg Engineering GmbH, F; Optovue, Inc., F; Topcon Medical Systems, Inc., F; Alcon Laboratories, Inc., C; Allergan, Inc., C; Diopsys, Inc., C; Optovue, Inc., C; Pfizer, Inc., C; Topcon Medical Systems, Inc., C.
  • Footnotes
    Support  Supported in part by the Lowell and Toby Harwood Research Fund of the New York Glaucoma Research Institute, New York, NY and Glaucoma Research and Education fund of Lenox Hill Hospital, New York, NY
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2681. doi:
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      S. M. Fernando, C. G. V. De Moraes, C. C. Teng, C. Tello, R. Ritch, J. M. Liebmann; Exfoliation Syndrome, Intraocular Pressure and Disc Hemorrhage. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2681.

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Abstract

Purpose: : To assess the relationship of unilateral disc hemorrhage (DH) and ocular parameters in subjects with bilateral exfoliation syndrome (XFS).

Methods: : The medical records and disc photographs of all patients seen in a glaucoma referral practice between January 1999 and October 2009 were reviewed by two glaucoma specialists. Age, ethnicity, presence or absence of XFS, CCT, visual field MD, intraocular pressure (IOP), and location of the DH were recorded.

Results: : We identified 40 subjects with unilateral DH and bilateral XFS. Mean age was 75.4±8.9 yrs, 27 (66%) were female, and 39 (98%) were of European descent. The majority of DH (25 eyes, 63%) occurred inferotemporally. There was no significant difference in spherical equivalent refractive error (-0.77±2.40 vs. -0.97±2.59 diopters, p=0.4), visual field mean deviation (-8.84±8.9 vs. -8.48±7.5 dB, p=0.6), or CCT (535.2±36.9 and 536.4±40.2 µm, p=0.7) in eyes with or without DH. Mean IOP prior to DH (17.2±3.7 vs. 15.9±3.7, p=0.004) and IOP at the time of DH detection (17.16±4.25 vs.15.08±5.08 mmHg, p=0.001) were higher in the DH eyes. There was a 45% (p=0.8) correlation between the DH eye and the eye with the worse visual field MD, 55% (p=0.9) between the location of the DH with the worse visual field hemifield, 43% (p=0.6) between the DH eye and the eye with worse XFS, and 65% (p=0.07) between the DH eye and the larger disc size. 72% (p=0.0003) of DH eyes had larger beta-zone parapapillary atrophy (PPA).

Conclusions: : In bilateral XFS, DH tended to occur in the eye with the higher IOP and the larger PPA. No other ocular parameters were identified that were associated with the occurrence of DH in bilateral XFS.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • optic nerve • intraocular pressure 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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