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M. A. Pickett, A. Harris, B. Siesky, Y. Shoshani, C.-W. Yung, D. WuDunn, R. Ehrlich, L. McCranor, J. Abrams, G. Eckert; Short Posterior Ciliary Artery Blood Flow Correlates With Visual Field AGIS Score Independent of Perfusion Pressure in Patients With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2688.
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To examine the relationship between retrobulbar blood flow and visual field damage in primary open angle glaucoma (OAG) patients.
An analysis of 116 patients with OAG (mean age 66.6; 70 female) participating in the Indianapolis Glaucoma Progression Study (IGPS) was performed during their initial baseline visit. Ocular perfusion pressures (systolic, diastolic and mean) were calculated and color Doppler imaging (CDI) of the nasal and temporal short posterior ciliary arteries was performed after Humphrey Visual Field Analyzer 24-2 standard automated perimetry (SITA) during a single study visit. The relationship between the peak systolic and end diastolic blood flow velocities and resistive index within ocular blood vessels and the visual field AGIS score and mean defect (MD) and pattern standard defect (PSD) was investigated for each patient.The strength of the linear association among these parameters was assessed using the Pearson Correlation Coefficients and P<0.05 were considered statistically significant.
Nasal short posterior ciliary artery end diastolic and temporal short poster ciliary artery peak systolic blood flow velocity were significantly negatively correlated with visual field AGIS score (r=-0.23, p=0.02; r=-0.24, p=0.01), respectively. Visual field MD was significantly correlated with nasal short posterior ciliary artery end diastolic blood flow velocity (r=0.21, p=0.02). Visual field MD was also significantly negatively correlated with nasal short poster ciliary artery vascular resistance (r=-0.20, p=0.04). Ocular perfusion pressures were not significantly correlated with visual field AGIS or MD.
In patients with glaucoma participating in the IGPS visual field damage was found to be correlated with both nasal and temporal short posterior ciliary artery blood flow. The short posterior ciliary arteries perfusing the pre-laminar and laminar regions of the optic nerve head are associated with visual field outcomes, possibly independent of perfusion pressure.
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