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Y. Yokoyama, T. Nakazawa, N. Aizawa, H. Takahashi, N. Fuse, K. Nishida; Significant Correlation of the Decreased Optic Nerve Head Microcirculation With the Damage of Visual Fields and the Loss of Nerve Fiber Layer in Patients With Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2693. doi: https://doi.org/.
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To investigate whether the microcirculation of optic nerve head was correlated to the damage of visual field or the axonal loss in the patients with primary open-angle glaucoma (POAG).
One hundred fifty eyes of 89 subjects; 96 glaucoma (Glaucoma Hemifield test: GHT outside normal limits, GHT+) and 54 control (GHT within normal limits, GHT-), were included in this study. The best-corrected visual acuity (BCVA) was measured with a standard Japanese decimal visual acuity chart. The microcirculation of optic nerve head was examined with a laser speckle flowgraphy (LSFG-NAVI, Softcare Ltd, Japan) and the mean blur rate (MBR) was calculated with the color map. The MBR of the optic disc was statistically compared between 3 groups (GHT-, GHT+ BCVA>0.7, GHT+ BCVA ≤0.7) with ANOVA followed by Scheffe post hoc test. The correlation between MBR and clinical parameters including age, BCVA, intraocular pressure (IOP), mean deviation (MD) of Humphrey perimeter, pattern standard deviation (PSD), and average thickness of retinal nerve fiber layer thickness (avg RNFLT) was evaluated with a Spearman rank correlation coefficient.
The MBR of the optic nerve head was 25.8±5.5 (n=54, GHT-), 19.8±5.2 (n=84, GHT+ BCVA>0.7), and 16.4±4.3 (n=12, GHT+ BCVA≤0.7), respectively. The data was significantly different between each groups (p<0.001). The correlation coefficients between MBR and BCVA (r=0.25, p=0.02), MD (r=0.48, p<0.001), PSD (r=-0.49, p<0.001), and avg RNFLT (r=0.50, p<0.001) were significant but not age (r=-0.01) and IOP (r=-0.19).
These results suggested that the decreased change of microcirculation in the optic nerve head was correlated with the visual field damage in the patients with glaucoma. In this study, we demonstrated that the level of MBR of LSFG-NAVI would be an indicator for detection of glaucomatous optic neuropathy.
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