April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Comparison of Ocular Perfusion Pressure in Normal Subjects and Glaucoma Patients Using Travoprost/timolol and Bimatoprost/Timolol Fixed Combination Before, During and After Aerobic Exercise
Author Affiliations & Notes
  • B. P. Figueiredo
    Glaucoma, Cataract, Santa Casa - Belo Horizonte / UFMG, Belo Horizonte, Brazil
  • N. V. Lima
    Glaucoma, Cataract, Hospital São Geraldo, UFMG – Minas Gerais, Belo Horizonte, Brazil
  • F. N. Kanadani
    Ophthalmology/Glaucoma, Santa Casa de Belo Horizonte/UNIFESP, Belo Horizonte, Brazil
  • H. H. Russ
    Glaucoma, Cataract, Instituto Graeffe – Curitiba – Paraná, Belo Horizonte, Brazil
  • T. C. M. Kanadani
    Retina, Cataract,
    Santa Casa - Belo Horizonte, Belo Horizonte, Brazil
  • E. R. Diniz
    Cornea, Cataract,
    Santa Casa - Belo Horizonte, Belo Horizonte, Brazil
  • A. Tupynambá
    Glaucoma, Cataract, Hospital de Base do Distrito Federal, Brasília, Brazil
  • S. K. Dorairaj
    Glaucoma, New York Eye and Ear Infirmary - New York, New York, New York
  • Footnotes
    Commercial Relationships  B.P. Figueiredo, None; N.V. Lima, None; F.N. Kanadani, None; H.H. Russ, None; T.C.M. Kanadani, None; E.R. Diniz, None; A. Tupynambá, None; S.K. Dorairaj, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2696. doi:https://doi.org/
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      B. P. Figueiredo, N. V. Lima, F. N. Kanadani, H. H. Russ, T. C. M. Kanadani, E. R. Diniz, A. Tupynambá, S. K. Dorairaj; Comparison of Ocular Perfusion Pressure in Normal Subjects and Glaucoma Patients Using Travoprost/timolol and Bimatoprost/Timolol Fixed Combination Before, During and After Aerobic Exercise. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2696. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To analyze and compare the influence of aerobic exercise on ocular perfusion pressure (OPP) in Normal subjects and primary open angle glaucoma patients treated with Ganfort and Duotrav.

Methods: : 45 patients [15 Normal subjects), and 30 glaucoma patients (15 treated with bimatoprost/timolol and 15 with travoprost/timolol)] were prospectively enrolled. OPP was calculated as 2/3 MAP-IOP. Intraocular pressure (IOP) by applanation tonometry and was measured before exercise, after 40 minutes of aerobic exercise and after 30 minutes of rest. For each patient the mean value of 2 measurements of the right eye was calculated and compared using the t-Test. P values < 0.05 were considered statistical significant.

Results: : Statistically significant IOP rise occurred in all groups during exercise (p < 0.0003). IOP recovery occurred more rapidly in controls and patients treated with bimatoprost/timolol compared to patients treated with travoprost/timolol [11.8 0.7 vs. 12.8 0.8 mmHg]. OPP was lower in normal subjects [45.4 3.0 mmHg] compared to bimatoprost/timolol [ 56.7 2.2 mmHg] and travoprost/timolol [ 52.4 2.0 mmHg] treated patients (p < 0.0001). All groups demonstrated a statistical significant OPP rise just after exercise [50.5 2.7; 69.3 3.0; 62.0 1.7 mmHg, respectively] and a significant OPP decline after 30 minutes rest [49.2 3.2; 62.0 2.1; 57.1 3.2 mmHg respectively].

Conclusions: : OPP increased significantly in normals and glaucoma patients under aerobic exercise and a partial recover occurred after 30 minutes of resting. There was a significant difference in all groups, where glaucoma patients under bimatoprost/timolol demonstrated the higher OPP values.

Keywords: optic flow 
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