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B. P. Figueiredo, N. V. Lima, F. N. Kanadani, H. H. Russ, T. C. M. Kanadani, E. R. Diniz, A. Tupynambá, S. K. Dorairaj; Comparison of Ocular Perfusion Pressure in Normal Subjects and Glaucoma Patients Using Travoprost/timolol and Bimatoprost/Timolol Fixed Combination Before, During and After Aerobic Exercise. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2696.
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To analyze and compare the influence of aerobic exercise on ocular perfusion pressure (OPP) in Normal subjects and primary open angle glaucoma patients treated with Ganfort and Duotrav.
45 patients [15 Normal subjects), and 30 glaucoma patients (15 treated with bimatoprost/timolol and 15 with travoprost/timolol)] were prospectively enrolled. OPP was calculated as 2/3 MAP-IOP. Intraocular pressure (IOP) by applanation tonometry and was measured before exercise, after 40 minutes of aerobic exercise and after 30 minutes of rest. For each patient the mean value of 2 measurements of the right eye was calculated and compared using the t-Test. P values < 0.05 were considered statistical significant.
Statistically significant IOP rise occurred in all groups during exercise (p < 0.0003). IOP recovery occurred more rapidly in controls and patients treated with bimatoprost/timolol compared to patients treated with travoprost/timolol [11.8 0.7 vs. 12.8 0.8 mmHg]. OPP was lower in normal subjects [45.4 3.0 mmHg] compared to bimatoprost/timolol [ 56.7 2.2 mmHg] and travoprost/timolol [ 52.4 2.0 mmHg] treated patients (p < 0.0001). All groups demonstrated a statistical significant OPP rise just after exercise [50.5 2.7; 69.3 3.0; 62.0 1.7 mmHg, respectively] and a significant OPP decline after 30 minutes rest [49.2 3.2; 62.0 2.1; 57.1 3.2 mmHg respectively].
OPP increased significantly in normals and glaucoma patients under aerobic exercise and a partial recover occurred after 30 minutes of resting. There was a significant difference in all groups, where glaucoma patients under bimatoprost/timolol demonstrated the higher OPP values.
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