April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Ocular Pulse Amplitude is Influenced by Internal Carotid Artery Stenosis
Author Affiliations & Notes
  • P. B. Knecht
    Ophthalmology,
    University Hospital Zurich, Zurich, Switzerland
  • M. Menghini
    Ophthalmology,
    University Hospital Zurich, Zurich, Switzerland
  • R. Baumgartner
    Neuroangiology,
    University Hospital Zurich, Zurich, Switzerland
  • K. Landau
    Ophthalmology,
    University Hospital Zurich, Zurich, Switzerland
  • Footnotes
    Commercial Relationships  P.B. Knecht, None; M. Menghini, None; R. Baumgartner, None; K. Landau, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2697. doi:
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      P. B. Knecht, M. Menghini, R. Baumgartner, K. Landau; The Ocular Pulse Amplitude is Influenced by Internal Carotid Artery Stenosis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2697.

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Abstract

Purpose: : To investigate, for the first time in a clinical routine setting, the influence of internal carotid artery (ICA) stenosis on ocular pulse amplitude (OPA) measurements.

Methods: : This was a prospective cohort study. 114 eyes of 57 patients with presumed ICA were included. The degree of ICA stenosis was determined by color duplex ultrasound, OPA was measured by dynamic contour tonometry. Measurements were taken on both sides. The degree of ICA stenosis in percent and OPA measurements were correlated. In addition, the differences between the OPA measurements in both eyes of an individual were correlated with the differences of right and left ICA stenosis measurements.

Results: : The degree of ICA stenosis and the OPA showed a significant negative correlation (pearson's r: -0.218, p = 0.020). The difference of the OPA measurements between both eyes of an individual showed a significant negative correlation with the difference between right and left ICA stenosis measurements (pearson's r: -0.530, p<0.0001).

Conclusions: : The OPA is influenced by the hemodynamic impairment due to stenosis of the ICA and might therefore be a valuable, non invasive screening parameter for asymptomatic internal carotid artery stenosis.

Keywords: neuro-ophthalmology: diagnosis • blood supply • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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