April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Spatial Oxygenation Mapping of the Optic Disc in Glaucoma by Multispectral Imaging
Author Affiliations & Notes
  • J. Denniss
    Faculty of Life Sciences,
    University of Manchester, Manchester, United Kingdom
  • I. Schiessl
    Faculty of Life Sciences,
    University of Manchester, Manchester, United Kingdom
  • V. Nourrit
    Faculty of Life Sciences,
    University of Manchester, Manchester, United Kingdom
  • C. Fenerty
    Faculty of Life Sciences,
    University of Manchester, Manchester, United Kingdom
    Manchester Royal Eye Hospital, Manchester, United Kingdom
  • D. B. Henson
    School of Medicine,
    University of Manchester, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships  J. Denniss, None; I. Schiessl, None; V. Nourrit, None; C. Fenerty, None; D.B. Henson, None.
  • Footnotes
    Support  College of Optometrists (UK) PhD Studentship (JD), Manchester Academic Health Sciences Centre (MAHSC) and the NIHR Manchester Biomedical Research Centre.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2730. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Denniss, I. Schiessl, V. Nourrit, C. Fenerty, D. B. Henson; Spatial Oxygenation Mapping of the Optic Disc in Glaucoma by Multispectral Imaging. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2730.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To present spatial optic disc oxygenation maps from a group of glaucoma patients and to demonstrate the correspondence between oxygenation maps and structural measures.

 
Methods:
 

Eleven patients (20 eyes, mean age 71 ± 8 years) with primary open-angle glaucoma, glaucomatous visual field defect, age >40 years, no other ophthalmic disease, and refractive error less than +/-5.00DS equivalent and/or 2.00DC were recruited from the clinics of Manchester Royal Eye Hospital, UK. Patients undertook HRT3 (Heidelberg Retina Tomograph, Heidelberg Engineering GmbH, Germany) and multispectral imaging of the optic disc. Multispectral imaging was carried out with a modified digital fundus camera system incorporating a 150W xenon arc light source and a fast-tuneable liquid crystal filter (Varispec, Cambridge Research Systems, UK). Images were taken with 8 different wavelengths of light selected according to the reflection properties of retinal blood components (range 496-700nm, total acquisition time <1.68s). Pixel-by-pixel oxygenation maps were calculated from the aligned multispectral images using the Beer-Lambert law.

 
Results:
 

Oxygenation maps were calculated for all 20 imaged eyes. In all eyes areas of low oxygenation were found to correspond to areas of cupping measured by the HRT3. The figure shows 2 typical examples where in the oxygenation maps (left) brighter areas represent higher oxygenation and darker areas represent lower oxygenation. These correspond well with the HRT3 topography images (right) where the red areas represents the areas of cupping.

 
Conclusions:
 

Spatial oxygenation maps calculated from multispectral images show correspondence to optic disc structures and may provide additional information on optic disc perfusion in glaucoma patients.  

 
Keywords: optic disc • imaging/image analysis: clinical • oxygen 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×