April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
The Influence of Race on the Detection of Glaucoma Using Scanning Laser Polarimetry With Variable Corneal Compensation in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma Study (DIGS)
P. P. Sassani; P. A. Sample; G. Vizzeri; B. Nguyen; R. N. Weinreb; F. Medeiros; C. A. Girkin; J. M. Liebmann; L. M. Zangwill
Author Affiliations & Notes
  • P. P. Sassani
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • P. A. Sample
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • G. Vizzeri
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • B. Nguyen
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • R. N. Weinreb
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • F. Medeiros
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • C. A. Girkin
    Ophthalmology, University of Alabama, Birmingham, Alabama
  • J. M. Liebmann
    Ophthalmology, NYU School of Medicine, New York, New York
  • L. M. Zangwill
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • Footnotes
    Commercial Relationships  P.P. Sassani, None; P.A. Sample, Carl Zeiss Meditec, F; Haag-Streit, F; Welch-Allyn, F; G. Vizzeri, None; B. Nguyen, None; R.N. Weinreb, Carl Zeiss Meditec, Inc., F; Heidelberg Engineering, GmbH, F; Novartis, F; Optovue, Inc, F; Topcon Medical Systems, Inc, F; Alcon Laboratories, Inc., C; Allergan, Inc., C; Carl Zeiss Meditec, Inc., C; Glaxo., C; Optovue, Inc, C; Pfizer, Inc., C; Topcon Medical Systems, Inc, C; F. Medeiros, Alcon Laboratories, Inc., F; Carl Zeiss Meditec, Inc., F; Pfizer, Inc., F; Alcon Laboratories, Inc., C; Allergan, Inc., C; Pfizer, Inc., C; Alcon Laboratories, Inc., R; Allergan, Inc., R; Carl Zeiss Meditec, Inc., R; Pfizer, Inc., R; Reicherts, Inc., R; C.A. Girkin, Alcon Laboratories, Inc., C; Allergan, Inc., C; Pfizer, C; Heidelberg Engineering, R; Optive, Inc., R; Carl Zeiss Meditec, Inc., R; Merck, Inc, R; J.M. Liebmann, Zeiss Meditec, Inc., F; Diopsys, Inc., F; Optovue, Inc., F; Topcon Medical Systems, Inc., F; Alcon Laboratories, Inc., C; Allergan, Inc., C; Diopsys, Inc., C; Optovue, Inc., C; Pfizer, Inc., C; Topcon Medical Systems, Inc., C; L.M. Zangwill, Carl Zeiss Meditec, Inc., F; Heidelberg Engineering, GmbH, F; Optovue, Inc., F; Topcon Medical Systems, Inc, F.
  • Footnotes
    Support  11008 (LMZ),EY08208 (PAS),EY14267 (PAS, CAG, JML)EY13959 (CAG) Merck, Eyesight Foundation of Alabama (CAG),Grants for participation's glaucoma medications (Alcon, Allergan, Pfizer, Merck, Santen)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2731. doi:
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      P. P. Sassani, P. A. Sample, G. Vizzeri, B. Nguyen, R. N. Weinreb, F. Medeiros, C. A. Girkin, J. M. Liebmann, L. M. Zangwill; The Influence of Race on the Detection of Glaucoma Using Scanning Laser Polarimetry With Variable Corneal Compensation in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma Study (DIGS). Invest. Ophthalmol. Vis. Sci. 2010;51(13):2731.

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Abstract

Purpose: : To compare the accuracy of Scanning Laser Polarimetry with Variable Corneal Compensation (GDx VCC) in discriminating between healthy eyes and eyes with glaucomatous visual field loss in patients from African and European descent

Methods: : The study included 1195 healthy eyes and 615 eyes with glaucomatous visual field defects participating in the ADAGES and DIGS. 952 (52.6 %) were patients of African decent (AD) and 858 (47.4 %) from European descent (ED). All individuals underwent visual field testing and GDx VCC imaging within 6 months of one another. Receiver operating characteristic curves (AUROC) were used to compare the diagnostic accuracy of each parameter in AD and ED participants.

Results: : Among the sixteen GDx VCC parameters studied, in AD eyes, the nerve fiber indicator (NFI) had the highest diagnostic accuracy in distinguishing between healthy eyes and eyes with predominantly early to moderate glaucomatous field loss (AUROC of 0.84), followed by TSNIT average (0.83) and superior maximum, superior normalized area, superior average and inferior normalized area (all 0.82). Similar results were found in ED eyes; the AUROC was largest for NFI (0.87), followed by superior normalized area, TSNIT average, superior average, inferior normalized area superior (all 0.82) and superior maximum (0.81).

Conclusions: : Despite known racial differences in optic disc size and corneal thickness, the diagnostic accuracy of GDx VCC parameters was similar in AD and ED eyes.

Keywords: imaging/image analysis: clinical • detection • nerve fiber layer 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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