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P. P. Sassani, P. A. Sample, G. Vizzeri, B. Nguyen, R. N. Weinreb, F. Medeiros, C. A. Girkin, J. M. Liebmann, L. M. Zangwill; The Influence of Race on the Detection of Glaucoma Using Scanning Laser Polarimetry With Variable Corneal Compensation in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma Study (DIGS). Invest. Ophthalmol. Vis. Sci. 2010;51(13):2731.
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To compare the accuracy of Scanning Laser Polarimetry with Variable Corneal Compensation (GDx VCC) in discriminating between healthy eyes and eyes with glaucomatous visual field loss in patients from African and European descent
The study included 1195 healthy eyes and 615 eyes with glaucomatous visual field defects participating in the ADAGES and DIGS. 952 (52.6 %) were patients of African decent (AD) and 858 (47.4 %) from European descent (ED). All individuals underwent visual field testing and GDx VCC imaging within 6 months of one another. Receiver operating characteristic curves (AUROC) were used to compare the diagnostic accuracy of each parameter in AD and ED participants.
Among the sixteen GDx VCC parameters studied, in AD eyes, the nerve fiber indicator (NFI) had the highest diagnostic accuracy in distinguishing between healthy eyes and eyes with predominantly early to moderate glaucomatous field loss (AUROC of 0.84), followed by TSNIT average (0.83) and superior maximum, superior normalized area, superior average and inferior normalized area (all 0.82). Similar results were found in ED eyes; the AUROC was largest for NFI (0.87), followed by superior normalized area, TSNIT average, superior average, inferior normalized area superior (all 0.82) and superior maximum (0.81).
Despite known racial differences in optic disc size and corneal thickness, the diagnostic accuracy of GDx VCC parameters was similar in AD and ED eyes.
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