April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Peripapillary and Macular Choroidal Thickness Measurements With Spectral Domain Optical Coherence Tomography in Glaucoma
Author Affiliations & Notes
  • E. A. Maul
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • D. S. Chang
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • H. A. Quigley
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  E.A. Maul, None; D.S. Chang, None; H.A. Quigley, None.
  • Footnotes
    Support  Heidelberg Engineering
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2748. doi:
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      E. A. Maul, D. S. Chang, H. A. Quigley; Peripapillary and Macular Choroidal Thickness Measurements With Spectral Domain Optical Coherence Tomography in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2748.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine whether choroidal thickness is reduced in glaucoma as previously described in histology studies.

 
Methods:
 

The Heidelberg Spectralis SD-OCT (Heidelberg, Germany) was used to obtain images of the choroid from individuals with glaucomatous visual field loss (VF) in at least one eye, and glaucoma suspects. A single horizontal macular scan line, and a circular scan (3.45mm in diameter) centered on the optic disc were used. Image quality was graded based on the visibility of the interface between the choroid and the sclera. Choroidal thickness was then measured from the outer aspect of the retinal pigment epithelium to the outer aspect of the delineated choroid using ImageJ software (NIH, Bethesda MD).

 
Results:
 

Thirty subjects (60 eyes) were imaged during a routine follow up visit to the Glaucoma Service at Wilmer Eye Institute. Average (SD) age was 64.4 (10.6) and 68.0 (12.1) years for glaucoma suspects and glaucoma patients respectively. We were able to obtain images from the macular and peripapillary regions of at least one eye in all patients, and obtained scans from both eyes in 26 out of 30 patients. All missed scans were attributable to media opacity. The delimitation of the posterior border of the choroid was graded as: Poor, fair or high quality in 12%, 21% and 67% of the macular scans; and in 5%, 69% and 26% of peripapillary scans respectively. One macular and one peripapillary image per patient were randomly selected and regraded for quality by a second operator with good agreement. (kappa= 0.74 and 0.70 for macular and peripapillary scans respectively) Choroidal thickness was similar when comparing glaucoma patients to glaucoma suspects. (Table 1)

 
Conclusions:
 

Choroidal thickness does not appear to be reduced in this population of glaucoma patients when compared to glaucoma suspects. Furthermore choroidal imaging with SD-OCT results in fair to high quality images in almost all patients.  

 
Keywords: choroid • imaging/image analysis: clinical 
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