April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Glaucoma Disease Significantly Related to Severity at Time of Diagnosis and Associated Risk Factors
Author Affiliations & Notes
  • P. J. Harasymowycz
    Ophthalmology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
    Montreal Glaucoma Institute, Montreal, Quebec, Canada
  • Y. Buys
    Ophthalmology, University of Toronto, Toronto, Ontario, Canada
  • R. Gaspo
    Pfizer Canada, Montreal, Quebec, Canada
  • K. Kwok
    Pfizer, New York, New York
  • D. Zhou
    Pfizer, New York, New York
  • T. Nguyen
    Pfizer Canada, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships  P.J. Harasymowycz, None; Y. Buys, None; R. Gaspo, None; K. Kwok, None; D. Zhou, None; T. Nguyen, None.
  • Footnotes
    Support  Unrestricted Grant Pfizer
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2767. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P. J. Harasymowycz, Y. Buys, R. Gaspo, K. Kwok, D. Zhou, T. Nguyen; Glaucoma Disease Significantly Related to Severity at Time of Diagnosis and Associated Risk Factors. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2767.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : It has previously been shown that the cost for treating glaucoma increases with disease severity. This study was designed to describe the severity of OAG at time of diagnosis in Canadian patients and to compare glaucoma risk factors by disease severity.

Methods: : This was a cross-sectional, non-interventional study. Eligible subjects with newly diagnosed and previously untreated OAG underwent a complete medical history and ocular examination. Disease severity was determined according to optic disc and VF characteristics as previously published by Damji et al (CJO 2003;38:189-97). Descriptive statistics of all variables for OAG were calculated. In order to assess which risk factors and/or ocular variables were associated with OAG severity, adjusted odds ratios (OR), along with 95% confidence intervals (CIs), were obtained from multiple logistic regression models in which a comparison between advanced OAG vs. early or moderate OAG was performed.

Results: : A total of 292 subjects with OAG were included: majority had primary OAG (69.2%). Other diagnoses included normal tension (22.3%), pseudoexfoliation (5.5%) and pigmentary glaucoma (3.1%). Overall, 51.7% of subjects had early, 27.1% had moderate and 20.9% had advanced OAG at time of diagnosis. The results of multiple logistic regression found that the odds ratios for advanced vs. early or moderate OAG for findings not associated with stage of disease included 5.17 (95% CI: 1.27-21.10, p=0.022) for disc pallor, 2.66 for presence of peripapillary atrophy (95% CI: 1.51-4.69; p=0.001), 2.60 (95% CI: 1.30-5.19, p=0.007) for presence of NFLD, 2.08 for localized notch or rim thinning (95% CI: 1.12-3.86; p=0.021), and 1.89 for presence of smoking (95% CI: 1.05-3.41; p=0.034).

Conclusions: : Almost half of the subjects with OAG presented with moderate or advanced disease at the time of diagnosis. Evaluation of the various risk factors found optic disc pallor, peripapillary atrophy, presence of a NFLD, localized notch or rim thinning and smoking to be significant.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.