April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
SD OCT Retinal Thinning is Accelerated in Early AMD and Associated With CSF Visual Decline
Author Affiliations & Notes
  • W. R. Stiles
    North Chicago VA Hospital, Northbrook, Illinois
  • S. P. Richer
    Eye Clinic 112E, DVA Medical Center, North Chicago, Illinois
  • J. Cho
    Rosalind Franklin University of Medicine & Science, North Chicago, Illinois
  • M. Levin
    North Chicago VA Hospital, North Chicago, Illinois
  • L. J. Ulanski, II
    Ophthalmology, Univ of Illinois, Chicago, Chicago, Illinois
  • M. J. Sinai
    Clinical Affairs, Optovue Inc, Carlsbad, California
  • C. Thomas
    North Chicago VA Hospital, North Chicago, Illinois
  • Footnotes
    Commercial Relationships  W.R. Stiles, None; S.P. Richer, Optovue, Stereo Optical, Kowa, Chrysantis, F; Stereo Optical, C; J. Cho, None; M. Levin, None; L.J. Ulanski, II, None; M.J. Sinai, Optovue, E; C. Thomas, None.
  • Footnotes
    Support  Chrysantis
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2784. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      W. R. Stiles, S. P. Richer, J. Cho, M. Levin, L. J. Ulanski, II, M. J. Sinai, C. Thomas; SD OCT Retinal Thinning is Accelerated in Early AMD and Associated With CSF Visual Decline. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2784.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Explore SD (spectral domain) OCT characteristics in early AMD using 2 observational case series clinical data sets, one with /without associated visual function data.

Methods: : EDTRS foveal, parafoveal & perifoveal retinal thickness in 54 primarily male AMD patients (n=98 eyes) spanning 4 decades (ages 49 to 88y) using the RTVue® SD OCT MM5 (15° x 15°) retinal thickness mode. A subset of 29 patients (n=56 eyes) had associated visual function and retinal grading data available from our completed ZVF research study (FDA IND# 78,973). Four Quadrant EDTRS sector data (Sup/Nas/Inf/Temp) compared to a larger dual gender, all ethnicity normative thickness set of (n= 1095 retinas, ages 18 - 81y) supplied by OptoVue, Inc (Fremont, CA). The AUC (area under the curve) distance photopic CSF was evaluated with a Stereo Optical, Inc (Chicago, IL) Vision Function Analyzer® with best corrective lenses.

Results: : Distinctive horizontal horseshoe-shaped parafoveal thinning occurred faster in AMD patients but significantly in the same quadrant order with the superior most vulnerable and the temporal least vulnerable (Sup Quad: -5.5u vs. -1.6u (norm), P<0.01; Nas: -5.1u vs. -1.5u, P<0.01; -Inf -3.9u vs. -1.4u P<0.02; Temp -2.5u vs. -0.8u P<0.13). The ZVF data set revealed the same accelerated overall thinning & quadrant order effect. While non - lenticular-corrected CSF declined steeply w age (r=-0.58, P<0.01), approximately 50% of the effect appears related to accelerated retinal thinning (AUC CSF vs. % Thinning, r=-0.33, P=0.01). Notably, the SD OCT thinning and CSF decline is in early AMD retinas with near normal Snellen acuity and minimal ophthalmoscopic disease (AREDS report #18 grade 1.43 (sd 0.92) / 4.0 scale).

Conclusions: : Pincer horizontal-oriented parafoveal SD OCT retinal thinning in primary GA & drusenoid AMD mirrors the pathological process described by Sarks and Sarks 20 years ago using serial FA, white light and EM (Eye 1988; 2: 552-77). It’s a new simple metric for early objective AMD diagnosis that correlates with CSF loss, a major measure of AMD visual disability.

Keywords: age-related macular degeneration • aging: visual performance • contrast sensitivity 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.