April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Efficacy of Autologus Serum Eye Drops in Post Prk Dry Eye Patients: A Confocal Microscopy Study
Author Affiliations & Notes
  • M. Marenco
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • C. Colica
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • F. Missiroli
    Ophalmology, Tor Vergata University of Rome, Rome, Italy
  • M. Esposito
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • E. Vingolo
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • P. Grenga
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • A. Missiroli
    Ophalmology, Sapienza University of Roma, Rome, Italy
  • Footnotes
    Commercial Relationships  M. Marenco, None; C. Colica, None; F. Missiroli, None; M. Esposito, None; E. Vingolo, None; P. Grenga, None; A. Missiroli, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2850. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. Marenco, C. Colica, F. Missiroli, M. Esposito, E. Vingolo, P. Grenga, A. Missiroli; Efficacy of Autologus Serum Eye Drops in Post Prk Dry Eye Patients: A Confocal Microscopy Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2850.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate the effect of autologus serum eye drops on corneal sub basal nerve plexus in patients with persistent dry eye following myopic PRK.

Methods: : 44 eyes of 22 patients who had dry eye symptoms that persisted at least 12 months after PRK were evaluated in the study. Patients were divided into 2 groups, each including 11 patients. The first group (A) has been treated with artificial eye drops (jaluronic acid 0.2 %) and the second group (B) has been treated with autologus serum eye drops for 12 months. Topical autologus serum was used 6 times per day. All patients underwent lacrimal evaluation (with Schirmer and BUT test), corneal sensation measurements using the Cochet-Bonnet esthesiometer and confocal microscopy of the sub basal nerve plexus using the Confoscan 3.0 (Nidek Technologies Vigonza, Italiy). 10 images at the level of the subepithelial nerve plexus in the central cornea were randomly selected for analysis of corneal nerves. The examinations were performed at baseline, at 1, 3, 6 and 12 months

Results: : At one month and at 3 months of treatment all patients of both groups showed improvement of dry eye symptoms, but no differences in corneal sensation was noted between the two groups (P = 0.003). At 3 months confocal microscopy showed an initial increase of regenerated nerves in sub basal nerve plexus only in 3 patients of the serum eye drop group (P= 0.08).An improvement of nerve plexus was evident at six months in all patients of serum group as well as increase of corneal sensation (P= 0.001). No changes in the control group was noted either in nerve plexus morphology and corneal sensation.At the end of treatment confocal images showed an increase of density of sub epithelial nerve as well as an improvement of nerve fiber thickness only in the serum group

Conclusions: : This study revealed that the efficacy of autolugus serum eye drops in the treatment of post PRK dry eye has been correlated to the improvement of sub basal nerve morphology as shown by in vivo confocal microscopy

Keywords: cornea: tears/tear film/dry eye • microscopy: confocal/tunneling • refractive surgery: PRK 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×