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M. Marenco, C. Colica, F. Missiroli, M. Esposito, E. Vingolo, P. Grenga, A. Missiroli; Efficacy of Autologus Serum Eye Drops in Post Prk Dry Eye Patients: A Confocal Microscopy Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2850.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of autologus serum eye drops on corneal sub basal nerve plexus in patients with persistent dry eye following myopic PRK.
44 eyes of 22 patients who had dry eye symptoms that persisted at least 12 months after PRK were evaluated in the study. Patients were divided into 2 groups, each including 11 patients. The first group (A) has been treated with artificial eye drops (jaluronic acid 0.2 %) and the second group (B) has been treated with autologus serum eye drops for 12 months. Topical autologus serum was used 6 times per day. All patients underwent lacrimal evaluation (with Schirmer and BUT test), corneal sensation measurements using the Cochet-Bonnet esthesiometer and confocal microscopy of the sub basal nerve plexus using the Confoscan 3.0 (Nidek Technologies Vigonza, Italiy). 10 images at the level of the subepithelial nerve plexus in the central cornea were randomly selected for analysis of corneal nerves. The examinations were performed at baseline, at 1, 3, 6 and 12 months
At one month and at 3 months of treatment all patients of both groups showed improvement of dry eye symptoms, but no differences in corneal sensation was noted between the two groups (P = 0.003). At 3 months confocal microscopy showed an initial increase of regenerated nerves in sub basal nerve plexus only in 3 patients of the serum eye drop group (P= 0.08).An improvement of nerve plexus was evident at six months in all patients of serum group as well as increase of corneal sensation (P= 0.001). No changes in the control group was noted either in nerve plexus morphology and corneal sensation.At the end of treatment confocal images showed an increase of density of sub epithelial nerve as well as an improvement of nerve fiber thickness only in the serum group
This study revealed that the efficacy of autolugus serum eye drops in the treatment of post PRK dry eye has been correlated to the improvement of sub basal nerve morphology as shown by in vivo confocal microscopy
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