April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Diffusion Tensor Magnetic Resonance Imaging and Fiber Tracking of Trigeminal Nerves in Relapsing Herpetic Keratouveitis
Author Affiliations & Notes
  • M. Labetoulle
    Ophthalmology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • G. Nasser
    Neuro-radiology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • I. De Monchy
    Ophthalmology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • G. Gendron
    Ophthalmology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • N. Pogorzalek
    Ophthalmology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • D. Ducreux
    Neuro-radiology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • F. Benoudiba
    Neuro-radiology,
    Center Hosp Univ Bicetre, Le Kremlin Bicetre, France
  • Footnotes
    Commercial Relationships  M. Labetoulle, None; G. Nasser, None; I. De Monchy, None; G. Gendron, None; N. Pogorzalek, None; D. Ducreux, None; F. Benoudiba, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 2890. doi:
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      M. Labetoulle, G. Nasser, I. De Monchy, G. Gendron, N. Pogorzalek, D. Ducreux, F. Benoudiba; Diffusion Tensor Magnetic Resonance Imaging and Fiber Tracking of Trigeminal Nerves in Relapsing Herpetic Keratouveitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2890.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the efficacy of diffusion tensor magnetic resonance imaging (DTMRI) for the analysis of trigeminal fibres (TGFs) in relapsing herpetic kerato-uveitis.

Methods: : The TGFs of 12 patients (average age: 57+/-16 years), addressed for relapsing unilateral kerato-uveitis related to Herpes simplex virus (HSV) or varicella-zoster virus (VZV), were tested using DTMRI. The diagnosis of HSV- or VZV-related disease was based on PCR or specific antibodies production within the aqueous humor, or on medical history (zoster). At the time of DTMRI, the kerato-uveitis was in a quiescent period (no recent increase of inflammation). Data were retrospectively assessed by a blinded examiner to compare the affected-side with the non-affected one, and with data from 21 sex- and age-matched normal subjects.

Results: : The DTRMI processing showed a significant difference in the mean anisotropic fraction (AF) of trigeminal fibres from the affected eye, compared to the controlateral side (0.40 versus 0.47, p = 0.003). In contrast, there was no significant asymmetry in control subjects (0.39 versus 0.43, p =0,09).

Conclusions: : DTMRI is a powerful technique for the analysis of neuronal networks in patients. Our results suggest that multiple HSV or VZV reactivation episodes induce persistent trigeminal fibres injuries (as shown by reduction of mean AF), that probably reflects a significant decrease in the amount of nerve endings.

Keywords: keratitis • herpes simplex virus • cornea: clinical science 
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