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B. D. Novosad, M. H. Elliott, M. C. Callegan; Toll-Like Receptor 2 (TLR2) Contributes to Intraocular Inflammation and Barrier Permeability During Experimental Bacillus cereus Endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2900.
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To determine the effect of TLR2 deficiency on intraocular inflammation and blood-retinal barrier permeability during experimental Bacillus cereus endophthalmitis.
100 colony forming units (cfu) of vegetative B. cereus were injected into the midvitreous of wild type (WT) C57BL6/J or homozygous TLR2-/- knockout mice. Ocular infections were analyzed by bacterial quantitation, histology, myeloperoxidase (MPO) activity, cytokine/chemokine quantitation, and quantitation of blood-retinal barrier permeability (N≥4 eyes per assay per time point, mean ± SEM).
The acute intraocular inflammatory response to B. cereus endophthalmitis was altered by the deficiency in TLR2. Impaired blood-retinal barrier permeability due to decreased VEGF levels in TLR2-deficient mice may have delayed this response, preventing the explosive inflammation typically seen during this infection.
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