Purchase this article with an account.
E. W. Norcross, M. E. Sanders, Q. C. Moore, III, C. M. Sanfilippo, C. K. Hesje, A. Shafiee, M. E. Marquart; Comparative Efficacy of Besifloxacin in a Prophylaxis Model of Penicillin-Resistant Streptococcus pneumoniae Rabbit Endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2901.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Fluoroquinolones show broad spectrum antibacterial activity and are used to treat a wide range of bacterial infections. However, studies have shown that pneumococcal strains with penicillin resistance were more likely to also show resistance to fluoroquinolones. To date there have been no in vivo studies regarding the efficacy of fluoroquinolones against penicillin-resistant S. pneumoniae endophthalmitis. Therefore, the aim of the study was to study the efficacy of topical administration of gatifloxacin (0.3%), moxifloxacin (0.5%) ophthalmic solutions, and besifloxacin (0.6%) ophthalmic suspension in the prophylaxis and treatment of penicillin-resistant pneumococcal endophthalmitis.
Four groups of New Zealand white rabbits were topically treated with gatifloxacin, moxifloxacin, besifloxacin, and PBS at the following time points: 60, 45, 30, and 15 minutes prior to infection, immediately after infection, and then 6, 12, 18, and 24 hours post-infection. Penicillin-resistant Streptococcus pneumoniae (106 CFU in 50 µl) were injected intracamerally. The severity of the infection was assessed by two masked observers 24 hours post-infection by clinical examination. Thereafter, aqueous and vitreous samples were collected, diluted, and plated to determine bacterial load (i.e., recovered CFU).
The three fluoroquinolones reduced clinical scores and bacterial load in the aqueous humor when compared to the PBS-treated eyes. No statistically significant differences were observed among all the fluoroquinolone-treated groups. Additionally, there was no statistically significant difference in bacterial load in the vitreous humor among the fluoroquinolones or when compared to PBS group.
Besifloxacin is as effective as moxifloxacin and gatifloxacin in a rabbit model for the prophylaxis and treatment for penicillin-resistant S. pneumoniae endophthalmitis after topical administration.
This PDF is available to Subscribers Only